CHORDOMA

This study tests a new way to deliver proton therapy for people with chordoma or chondrosarcoma at the base of the skull. Instead of many small doses, patients receive 5 high-precision treatments. The goal is to see if this approach controls tumor growth while reducing side effec…

This study compares carbon ion therapy, surgery, and proton therapy for people with pelvic bone sarcomas (cancers like chordoma or osteosarcoma). The goal is to see which treatment provides better quality of life and disease control with fewer side effects. About 72 participants …

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid to help the donor cells fight solid tumors that have come back or not responded to treatment. It includes children and young adu…

This study compares two standard treatments—surgery and radiation therapy—for people with a rare tumor at the base of the spine called sacral chordoma. About 100 adults with newly diagnosed, localized disease will be followed to see which approach better prevents the tumor from c…

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This study follows 300 people aged 2 and older with chordoma, a rare bone cancer of the skull or spine. Researchers will track how the disease changes over time using scans, exams, and surveys. The goal is to better understand chordoma so future treatments and care can be improve…