CHOLANGIOCARCINOMA

This early-phase study tests a new treatment called TCR1188-ABC for people with certain advanced cancers (pancreatic, colorectal, lung, or bile duct) that have a specific genetic change called KRAS G12V. The treatment uses a patient's own immune cells, modified in a lab to better…

This study tests whether combining two drugs—adebrelimab (given by IV) and S-1 (taken as pills)—can help prevent bile duct cancer from returning after surgery. About 40 adults who had their cancer completely removed will receive the treatment for about 4 months. Researchers will …

This study tests whether using a special test (3D-PTA) on a patient's tumor can help doctors pick the most effective chemotherapy after surgery for stage II/III bile duct cancer. About 98 adults who had their cancer fully or nearly fully removed will be randomly assigned to eithe…

This study tests if adding a targeted drug (becotatug vedotin) to standard chemotherapy and immunotherapy helps shrink tumors better than standard treatment alone in people with advanced bile duct cancer that has a specific gene change (EGFR mutation). About 164 adults with this …

This study tests two drugs together for people with advanced bile duct cancer that has not responded to prior treatment. The goal is to see if the combination can shrink tumors and control the disease. About 60 adults will take part, and the study will monitor side effects and su…

This study compares two ways to drain bile in people with bile duct blockages caused by cancer. One method places a tube across the bile duct opening into the intestine, while the other uses a metal stent that stays above the opening. The goal is to see which method causes fewer …

This study will create a biobank by collecting blood, tissue, and other samples from 300 people with liver, bile duct, or pancreatic tumors, as well as from people with benign conditions and healthy volunteers. No experimental treatments or extra procedures are involved—samples a…

This study looks at whether an improved endoscopic ultrasound (EUS) can better detect cancer in the lymph nodes of people with bile duct cancer before they have surgery. About 250 adults with presumed removable bile duct cancer will get this enhanced EUS. The main goal is to see …

This study looks at how to safely test for allergic reactions to biotherapy drugs in cancer patients. Researchers will find the highest skin test dose that does not cause irritation in most people. The goal is to create clear guidelines for doctors to diagnose allergies to these …

This study will follow 1,000 adults who have liver or bile duct surgery at San Jacopo Hospital in Pistoia. Researchers will track complications, survival, and cancer recurrence for up to 5 years. The goal is to better understand how patients recover and their long-term outcomes a…

This study looks at whether blood tests that detect cancer DNA (ctDNA) and patient-reported quality of life can help predict how bile duct cancer will progress and how well treatment is working. Researchers will collect blood samples and questionnaires from 300 patients with cura…