Chemotherapy induced peripheral neuropathy (CIPN)

This trial tests whether applying cooling cuffs to the hands and feet during weekly paclitaxel chemotherapy can reduce nerve damage in women with breast cancer. Participants are randomly assigned to receive cryotherapy or standard care, and their nerve function is tracked through…

This study tests whether soaking feet in cold salt water can prevent nerve damage caused by the chemotherapy drug paclitaxel in breast cancer patients. Thirty women will be split into three groups: cold salt water foot baths, cold unsalted water foot baths, or standard care. The …

This study tests whether wearing compression gloves and stockings during chemo, plus acupuncture after, can prevent nerve damage (peripheral neuropathy) in breast cancer patients. About 384 people will be randomly assigned to one of four groups: compression only, acupuncture only…

Researchers test whether adding rectal ozone therapy to usual care can reduce numbness and tingling in people with chemotherapy-induced peripheral neuropathy. The trial enrolls 42 adults whose cancer is stable or in remission and who have had persistent numbness or tingling for a…

This study tests whether combining electro-acupuncture with a structured exercise program helps cancer survivors manage chemotherapy-induced peripheral neuropathy (CIPN) — nerve damage causing numbness, pain, and balance problems in hands and feet. Participants receive either ele…

This study tests special gloves and boots that gently squeeze the hands and feet during chemotherapy. The pressure may reduce how much chemo reaches the nerves, possibly preventing pain and numbness. About 142 adults with cancer will try the devices to see if they help avoid nerv…

This study tests whether a 10-week virtual exercise program can reduce nerve pain and improve daily activities in cancer survivors who have persistent nerve damage from chemotherapy. About 240 participants will either receive the program or usual care. The program includes person…

This study tests whether a 12-week virtual tai chi program is practical and acceptable for cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN), which causes pain, numbness, and balance problems. Researchers plan to enroll 21 participants who have completed che…

This study tests whether taking two dietary supplements (PEA and Scutellaria) along with a structured exercise program can reduce nerve pain and damage caused by chemotherapy. About 40 adult cancer survivors who have nerve pain will be followed for 60 days. The goal is to see if …

This study is testing whether a closed-loop spinal cord stimulator can reduce pain and improve quality of life in people with nerve damage from chemotherapy. The device automatically adjusts stimulation based on nerve responses. Twenty adults with persistent pain will be followed…

This study aims to see if a quick bedside sensory test can predict which painkiller—pregabalin, duloxetine, or a placebo—works best for people with nerve pain in their feet. About 190 adults with diabetic, chemotherapy-related, or idiopathic nerve pain will try each treatment for…

This study will assess physical function in 80 people with chemotherapy-induced peripheral neuropathy (CIPN) using tests like balance, walking, and grip strength. Researchers will compare these objective measures with patients' own symptom reports to develop better ways to track …

This early-stage trial tests the safety and tolerability of a single dose of AH-008, a potential treatment for chemotherapy-induced peripheral neuropathy (nerve damage). Healthy adults aged 18 to 65 receive either AH-008 or a placebo by intravenous infusion. The study monitors si…

This study looks at whether measuring big toe strength can help doctors understand nerve damage caused by chemotherapy (called CIPN). Researchers will compare 30 people with CIPN to healthy adults using a special device called ToeScale. Participants will also answer questionnaire…