CHEMOTHERAPY

This study tests whether adding a probiotic called Lactobacillus johnsonii to standard chemotherapy and immunotherapy can help control advanced lung, breast, or stomach cancers. About 156 adults with these cancers will be randomly assigned to receive either the probiotic or a pla…

This study tests whether adding a special type of radiation (quad shot radiotherapy) to a drug called QL1706 (which boosts the immune system) plus standard chemotherapy can better control advanced non-small cell lung cancer. About 104 people with stage IV lung cancer that has not…

This study tests a new three-drug combination for people with advanced esophageal squamous cell carcinoma (ESCC). The drugs include a targeted therapy (becotatug vedotin), an immunotherapy (tislelizumab), and standard chemotherapy. The goal is to see if this combo shrinks tumors …

This study tests a new approach for people with stage III non-small cell lung cancer that cannot be removed with surgery. Participants receive a combination of an immunotherapy drug (tislelizumab), standard chemotherapy, and a targeted procedure that delivers chemotherapy directl…

This study tests a drug called entinostat combined with chemotherapy for people with advanced bladder cancer that has not responded to initial treatment. The goal is to see if this combination can shrink tumors or slow the disease. About 29 participants will receive the treatment…

This study compares three simple topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—to prevent phlebitis (vein inflammation) caused by chemotherapy. About 190 adults with breast or colon cancer receiving certain chemo drugs through a peripheral IV will be en…

This study tests whether the drug sotagliflozin can prevent heart, muscle, and fat damage caused by a common type of chemotherapy (anthracycline) in people with newly diagnosed lymphoma. About 60 participants will receive either the drug or a placebo during their first round of c…

This study tests if a special exercise program, done before starting chemotherapy, can help prevent or reduce memory loss and brain fog (chemo brain) in older adults with colorectal cancer. The study will include 86 people aged 60-85 who are not currently active. Researchers will…

This study looks at how platinum-based chemotherapy can cause permanent hearing loss in cancer patients, especially those from poorer backgrounds. Researchers will test hearing and thinking skills in 172 patients from North West England before and after treatment. The goal is to …

This study aims to understand how people getting chemotherapy at a clinic (without staying overnight) feel about the nursing care they receive. Researchers will interview 10 to 20 adults to learn what 'individualized care' means to them and how it affects their treatment experien…

This study will observe how adults receiving chemotherapy use digital media and how skilled they are at finding and understanding health information online. Researchers will survey 80 patients to learn about their digital habits and eHealth literacy. The goal is to better underst…