CERVICAL CARCINOMA

This study tests the drug pembrolizumab in about 1,600 people with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can shrink tumors and to identify biomarkers that predict response. Participants receive pembrolizumab and are m…

This early-stage study tests an experimental pill, ATV-1601, in people with advanced solid tumors (including certain breast, ovarian, and prostate cancers) that have a specific AKT1 gene mutation. The main goals are to check the drug's safety, find the best dose, and see how the …

This study tests a drug called XmAb20717 in 140 adults with advanced rare cancers, including mesothelioma, cervical cancer, and Hodgkin's lymphoma. The goal is to see if the drug can shrink tumors and how safe it is. Participants must have measurable disease and be able to follow…

This study tests a combination of two drugs (zimberelimab and lenvatinib) in 30 people with advanced cervical cancer that got worse after prior immunotherapy. The goal is to see if this combo can shrink tumors or slow the disease. Participants must have tried platinum-based chemo…

This study compares the accuracy of self-collected vaginal samples versus doctor-collected cervical samples for HPV testing in 750 people referred for colposcopy or cervical procedures. The goal is to see if self-collection is a reliable, more comfortable option to increase scree…

This study compares the accuracy of HPV testing on self-collected vaginal samples versus samples collected by a doctor during a pelvic exam. About 500 people referred for colposcopy or cervical procedures will provide both types of samples. The goal is to see if self-collection i…

This study looks at whether women can collect their own vaginal samples for HPV testing instead of having a doctor collect them during a pelvic exam. About 500 people referred for colposcopy or cervical procedures will provide both a self-collected sample and a doctor-collected s…

This study looks at whether giving women a simple self-collection kit for HPV testing at Express Care clinics (which have evening and weekend hours) can increase the number of women who get screened for cervical cancer. About 500 women ages 30–63 who are overdue for screening wil…

This study looks at whether women in Uganda can prevent cervical cancer by using a self-administered HPV test at home or in community health campaigns. The test checks for the virus that can lead to cervical cancer, allowing early treatment. Over 2,500 women aged 25-49 are taking…

This early-phase study tests a new imaging tracer called 68Ga-FAPI-46 in 26 people with various cancers. The tracer targets cells around tumors, helping PET scans show where cancer is located. Researchers want to see how well the tracer works and compare it to standard imaging. T…

This study follows thousands of women in Costa Rica who received the HPV vaccine years ago, plus a new group of unvaccinated women, to see how well the vaccine works over time. Researchers are checking for cervical cell changes, immune markers, and whether the vaccine might shift…

This study follows 72 women with pelvic cancers (like cervical, rectal, or anal cancer) who are receiving radiation therapy. Researchers measure physical changes in the vagina and collect surveys about sexual function, intimacy, and quality of life before treatment and up to 2 ye…

This study tests whether analyzing the genes in a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers (solid tumors, lymphoma, or myeloma) had their tumors genetically screened. Those with specific genetic c…

This study follows 79 women with gynecologic cancers (cervical, endometrial, vaginal, or vulvar) who had a pelvic exenteration—a surgery removing the lower colon, rectum, and bladder. Researchers track complications, quality of life, and cancer recurrence over time to learn which…