Cardiopulmonary bypass

This study compares cold-stored platelets to standard room-temperature platelets for controlling bleeding in adults after heart surgery. About 150 patients will be randomly assigned to receive one type. The goal is to see if cold storage is a safe and effective option, and to pla…

This study tests a new way to manage blood flow and oxygen in children right after heart surgery. The goal is to help their bodies use oxygen better during the critical first 8 hours, which may prevent dangerous drops in blood pressure or heart function. About 300 children weighi…

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This observational study looks at how lowering body temperature during heart-lung bypass surgery affects two common brain monitors (BIS and PSI). Researchers will track 60 adults undergoing planned coronary bypass surgery. The goal is to see if the monitors' readings change diffe…

This study looks at how red blood cells break down during prolonged heart-lung bypass in cardiac surgery, releasing free hemoglobin into the blood. Researchers will measure these levels and related proteins in adults undergoing complex heart procedures to see if they can predict …

This study tests whether a newer, less invasive heart-lung machine (MiECC) reduces brain swelling and stroke risk compared to the standard machine used during open heart surgery. Researchers will measure optic nerve sheath diameter (a marker of brain pressure) and track strokes o…

This study is looking at whether an artificial intelligence tool can help doctors decide which heart surgery patients might benefit from a drug called ulinastatin. Ulinastatin is used to reduce inflammation after surgery, but it doesn't work for everyone. Researchers will analyze…