BREAST DUCTAL CARCINOMA IN SITU

This study tests a vaccine called H2NVAC in people with a very early form of breast cancer called DCIS that has the HER2 protein. The vaccine is given before surgery to see if it can train the immune system to fight the cancer and possibly prevent it from coming back. The main go…

This study looks at whether cutting calories while getting focused radiation (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to one of two groups. The goal is to see if the diet hel…

This study tests a new glowing needle that helps doctors find and sample very small abnormal areas inside breast ducts during surgery. The needle has a special coating that lights up, making it easier to see and remove the right tissue. About 300 women having breast duct surgery …

This study is for premenopausal women at higher-than-average risk for breast cancer. It tests whether a low dose of tamoxifen, adjusted based on each woman's response, can safely reduce breast density—a key risk factor for breast cancer. About 200 women will take part, and the go…

This study looks at whether taking low-dose tamoxifen, alone or with high-dose omega-3 fatty acids, can lower breast cancer risk in overweight or obese postmenopausal women who are already at higher risk. About 66 women will take part. The goal is to see if adding omega-3s improv…

This study tests two drugs, acolbifene and low-dose tamoxifen, to see which works better at preventing breast cancer in premenopausal women at high risk. Both drugs block estrogen from fueling breast cell growth. About 80 women will take one of the drugs for six months, and resea…

This study tests a high-CBD plant extract (BRC-001) to see if it can reduce joint pain and stiffness in women with breast cancer who take aromatase inhibitors (AIs). AIs lower estrogen to prevent cancer return but often cause arthritis-like side effects, leading some women to sto…

This study looks at how the COVID-19 pandemic impacted the financial burden on breast cancer patients having surgery. Researchers will survey 600 patients about out-of-pocket costs, lost wages, and economic strain. The goal is to understand the financial challenges these patients…

This study is testing a patient navigation program for 126 newly diagnosed breast cancer patients. The program helps patients understand their care options, connect with support services, and overcome barriers to treatment. The goal is to see if this approach can improve health e…

This study offers free genetic testing to the general public to find people with inherited cancer syndromes like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500 …