BRCA2 GENE MUTATION
Clinical trials for BRCA2 GENE MUTATION explained in plain language.
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New drug shows promise in shrinking ovarian tumors before surgery
Disease control OngoingThis early-phase trial is testing the drug olaparib in 15 people with newly diagnosed BRCA-mutant ovarian, fallopian tube, or peritoneal cancer. Participants take olaparib for two cycles before their planned surgery to see if it can shrink tumors and is safe. The goal is to find …
Matched conditions: BRCA2 GENE MUTATION
Phase: EARLY_PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 26, 2026 07:52 UTC
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New drug combo targets prostate cancer in understudied groups
Disease control TerminatedThis study was designed to test a combination of two drugs, niraparib and abiraterone plus prednisone, in Hispanic/Latino and Black patients with a specific type of metastatic prostate cancer that has certain gene mutations. The goal was to see if the treatment could lower PSA le…
Matched conditions: BRCA2 GENE MUTATION
Phase: PHASE2 • Sponsor: Qian Qin • Aim: Disease control
Last updated May 22, 2026 14:03 UTC
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New hope for hard-to-treat cancers with BRCA gene changes
Disease control OngoingThis study tests a drug called talazoparib in 150 adults whose advanced cancer has stopped responding to standard treatments. The drug works by blocking an enzyme that helps tumor cells survive, and is given to people whose tumors have specific changes in BRCA or related genes. T…
Matched conditions: BRCA2 GENE MUTATION
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 22, 2026 13:55 UTC
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New hope for hard-to-treat cancers? drug targets tumors with unstable genes
Disease control OngoingThis study tests the drug pembrolizumab in 21 adults with advanced solid tumors that have specific gene mutations (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or control the cancer. Pembrolizumab is a type of immunotherapy that helps the immune system…
Matched conditions: BRCA2 GENE MUTATION
Phase: PHASE2 • Sponsor: Rutgers, The State University of New Jersey • Aim: Disease control
Last updated May 12, 2026 13:39 UTC
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Can healthy habits cut cancer risk? new study tests lifestyle programs
Prevention OngoingThis study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which program works best to improve waist size and overall health, whi…
Matched conditions: BRCA2 GENE MUTATION
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Prevention
Last updated May 26, 2026 07:52 UTC
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Genetic counseling by phone may ease cancer worry in High-Risk women
Knowledge-focused TerminatedThis study looks at whether watching an online genetics video, with or without phone counseling, can reduce the stress women feel about their cancer risk. It involves 5,200 women aged 30 or older who have had triple-negative breast cancer and still have at least one ovary. Resear…
Matched conditions: BRCA2 GENE MUTATION
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 26, 2026 07:23 UTC