BRCA1 GENE MUTATION
Clinical trials for BRCA1 GENE MUTATION explained in plain language.
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New hope for hard-to-treat cancers? drug targets gene glitches in advanced tumors
Disease control OngoingThis phase 2 study tests the drug pembrolizumab in 21 people with advanced solid tumors that have specific gene changes (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or stop the cancer from growing. This is not a cure, but a way to control the disease.
Matched conditions: BRCA1 GENE MUTATION
Phase: PHASE2 • Sponsor: Rutgers, The State University of New Jersey • Aim: Disease control
Last updated May 01, 2026 16:01 UTC
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New hope for tough cancers: drug targets BRCA mutations
Disease control OngoingThis study tests a drug called talazoparib in people with advanced cancers that have not responded to standard treatments. The drug works by blocking an enzyme that helps cancer cells survive, especially in tumors with changes in the BRCA genes or related DNA repair genes. The go…
Matched conditions: BRCA1 GENE MUTATION
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 01, 2026 15:59 UTC
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New drug combo targets tough prostate cancer in understudied groups
Disease control TerminatedThis study was designed to test a combination of two drugs (niraparib and abiraterone plus prednisone) in Hispanic/Latino and Black patients with metastatic hormone-sensitive prostate cancer that has certain gene mutations. The goal was to see if the treatment could lower PSA lev…
Matched conditions: BRCA1 GENE MUTATION
Phase: PHASE2 • Sponsor: Qian Qin • Aim: Disease control
Last updated Apr 30, 2026 15:51 UTC
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New drug shows promise in shrinking ovarian tumors before surgery
Disease control OngoingThis early-phase trial tests the drug olaparib in 15 people with newly diagnosed BRCA-mutant ovarian, fallopian tube, or peritoneal cancer. Participants take olaparib for two cycles before their planned surgery to see if it can shrink tumors safely. The goal is to find out if thi…
Matched conditions: BRCA1 GENE MUTATION
Phase: EARLY_PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 29, 2026 15:03 UTC
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Genetic counseling by phone may ease cancer fears
Knowledge-focused TerminatedThis study looks at whether watching an online genetics video, with or without phone counseling, can help reduce the stress women feel about their cancer risk. It involves 5,200 women aged 30 or older who have had triple-negative breast cancer and still have at least one ovary. R…
Matched conditions: BRCA1 GENE MUTATION
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 01, 2026 16:01 UTC