BONE SARCOMA

This study compares carbon ion therapy, surgery, and proton therapy for people with pelvic bone sarcomas (cancers like chordoma or osteosarcoma). The goal is to see which treatment provides better quality of life and disease control with fewer side effects. About 72 participants …

This early-phase study tests a technique called in vivo lung perfusion (IVLP) that delivers chemotherapy directly into the lung during surgery to remove sarcoma tumors that have spread to the lungs. The goal is to kill any microscopic cancer cells left behind, which standard surg…

This study tests whether the drug regorafenib, taken for up to 12 months, can help control high-grade bone sarcomas (a type of bone cancer) in patients whose tumors did not fully disappear after standard treatments. About 36 participants aged 12 and older will receive regorafenib…

This study is for people with bone sarcomas who have finished their first round of treatment. It tests whether taking the drug regorafenib for up to 12 months can help keep the cancer from returning, compared to just being watched. About 168 participants will be randomly assigned…

This early-phase trial tests a new treatment called attIL12 T-cell therapy for people with advanced soft tissue or bone sarcoma that has spread. The therapy uses the patient's own immune cells, modified to attack the cancer. The main goal is to find a safe dose and see if it can …

This study tests whether a dye injected during surgery can help doctors see if any cancer cells remain after removing a sarcoma. About 50 adults with bone or soft tissue sarcoma will take part. The dye's accuracy will be compared to standard lab results.

This study looks at whether offering mental healthcare early during sarcoma treatment can help reduce depression and anxiety and improve quality of life. About 60 adults with bone or soft tissue sarcoma who are scheduled for surgery will take part. Researchers will check how many…

This study looks at how people who had limb-saving surgery for sarcoma (a rare cancer) in their leg move and feel in daily life. Researchers will measure walking patterns, physical function, and quality of life in 60 adults who are at least one year past surgery. The goal is to l…

This study follows 300 people who had surgery to remove bone tumors and then had reconstruction using bone grafts or artificial parts. Researchers will measure how well the bone heals and how much function returns over 3 years. The goal is to learn more about recovery after these…