BILE DUCT CANCER

This study tests whether adding an immune-boosting drug (PDS01ADC) to standard liver-directed chemotherapy can help people with certain cancers that have spread to the liver. About 70 adults with colorectal, bile duct, or adrenal cancer will receive treatment through a pump place…

This study tests a new drug (CDX-1140) combined with three other drugs (capecitabine, oxaliplatin, and Keytruda) in people with advanced biliary tract cancer (bile duct cancer). The goal is to find a safe dose and see if the combination can shrink tumors or slow the disease. Abou…

This study tests whether using a special surgical glue (Glubran 2) during pancreas surgery can reduce the risk of a dangerous leak from the pancreas. About 194 adults with a soft pancreas who need surgery for cancer will be randomly assigned to receive the glue or standard care. …

This study tests a combination of four drugs (gemcitabine, cisplatin, zimberelimab, and quemliclustat) as a first treatment for people with advanced bile duct cancer that has not spread or come back after prior therapy. About 33 to 39 participants will receive the drugs in cycles…

This study is for people with a type of bile duct cancer that cannot be removed by surgery or has spread. It combines three treatments: tiny radioactive beads placed in the liver (Y-90), an immunotherapy drug (durvalumab), and two chemotherapy drugs (gemcitabine and cisplatin). T…

This study tests a new approach for people with a type of bile duct cancer that is difficult to remove with surgery. Participants receive a combination of targeted radiation, immunotherapy (tislelizumab), and chemotherapy before any surgery. The goal is to shrink the tumor enough…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve daily life in people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. The goal is to see if …

This study collects tumor and normal tissue samples from people already scheduled for surgery or biopsy at the NIH Clinical Center. The goal is to provide researchers with biological material to discover new molecular targets for cancer therapies. Up to 1800 adults and children (…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…