AUTONOMIC FAILURE

This study is testing if applying gentle, controlled heat to the abdomen at night can safely lower high blood pressure in people with autonomic failure, a rare nerve disorder. Researchers will compare the effects of real heat versus a sham (fake) treatment in 20 participants. The…

This study is testing if a CPAP machine, commonly used for sleep apnea, can quickly lower high blood pressure when patients with autonomic failure lie down. It will involve about 12 patients trying different air pressure levels from the CPAP while their blood pressure is monitore…

This study is investigating how abdominal compression garments help people with autonomic failure manage low blood pressure when standing up. Researchers will compare the effects of abdominal compression to standard medication (midodrine) in 29 participants. The goal is to unders…

This study compares two common treatments for low blood pressure when standing up in people with autonomic nervous system disorders. Researchers will test whether a medication called midodrine or wearing an abdominal compression binder works better to improve blood flow and reduc…

This study is testing a simple, non-drug approach to help people with autonomic failure who have dangerously high blood pressure when lying down. Researchers are comparing two ways of raising the head of the bed to see which one best lowers nighttime blood pressure. The goal is t…

This study is testing a new inflatable belt worn around the abdomen to see if it safely helps people with autonomic failure stand up without getting dizzy or fainting. Researchers will compare the real belt to a 'sham' belt with very low pressure in about 31 participants. The goa…

This study is testing if a CPAP machine, commonly used for sleep apnea, can help people with autonomic failure. These patients often have dangerously high blood pressure when lying down and severe dizziness when standing up. Researchers want to see if using CPAP at night can safe…

This study uses a special brain scan to measure dopamine activity in people with autonomic failure conditions like Parkinson's disease, multiple system atrophy, and Lewy body dementia. Researchers want to see if these scans can detect early changes that might predict which patien…

This study aims to understand how two existing medications, midodrine and droxidopa, affect blood flow in the abdomen of people with autonomic failure, a rare nerve disorder that causes severe drops in blood pressure when standing. Researchers will compare the drugs' effects on 3…