AUTONOMIC FAILURE

This study tests whether applying gentle heat to the abdomen overnight can safely lower high blood pressure that occurs when lying down in people with autonomic failure. About 20 adults with conditions like Parkinson's or Multiple System Atrophy who have this nighttime blood pres…

This study looks at whether raising the head of the bed can help lower high blood pressure that occurs when lying down (supine hypertension) in people with autonomic failure. By using gravity to reduce blood flow returning to the heart, researchers hope to find a non-drug way to …

This study tests a simple device that lets people breathe in a little extra carbon dioxide (CO2) to raise blood pressure. It is for people with neurogenic orthostatic hypotension, a condition where blood pressure drops sharply when standing, causing dizziness or fainting. About 2…

This study looks at whether a CPAP machine, often used for sleep apnea, can safely lower high blood pressure that happens when people with autonomic failure lie down. About 12 adults with this condition will try CPAP while resting. The goal is to see if their blood pressure drops…

This study looks at whether using a CPAP machine (commonly used for sleep apnea) can help people with autonomic failure who have high blood pressure when lying down and low blood pressure when standing. About 59 adults aged 40-80 with conditions like Parkinson's or multiple syste…

This study looks at how midodrine and droxidopa, two drugs used for low blood pressure upon standing, affect the veins in the abdomen of people with autonomic failure. About 34 adults aged 40-80 with conditions like multiple system atrophy, pure autonomic failure, or Parkinson di…

This study uses a special PET scan to measure dopamine production in the brains of people with autonomic failure, including those with Parkinson's disease, Multiple System Atrophy, or Dementia with Lewy Bodies. The goal is to find early signs that predict if a person with pure au…