ASTROCYTOMA

This study tests a drug called tuvusertib in people whose IDH-mutant astrocytoma (a type of brain tumor) has returned after initial treatment. The drug targets a specific genetic change (ATRX mutation) to try to stop the tumor from growing. About 56 adults will take part, and the…

This study follows children who have already taken dabrafenib and/or trametinib for certain brain tumors. Researchers will monitor side effects and track growth over time. The goal is to understand the long-term safety of these medications in young patients.

This study tests a combination of two drugs—ATRA and retifanlimab—in people with a type of brain tumor (glioma) that has come back after standard treatment. The goal is to see if this combination can shrink tumors or slow their growth by boosting the body's immune response. About…

This early-stage trial tests a specially engineered virus, G207, in children and young adults (ages 3 to 21) whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is …

This early-phase study tests a new approach for people with recurrent high-grade astrocytoma, a serious brain cancer. Participants receive a virus-based gene therapy injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the safest…

This early-phase trial tests a new drug called FT536 for adults with a severe type of brain cancer (WHO Grade 4 astrocytoma) that has come back after standard treatment. The drug is injected directly into the tumor during surgery. The main goal is to see if it is safe and tolerab…

This study tests a shorter, more intense radiation schedule for people whose glioblastoma (a severe brain cancer) has returned after standard treatment. About 28 adults will receive radiation 4 times a week for 1 to 3 weeks. The goal is to find the safest dose that controls the t…

This study tests whether the blood thinner apixaban can safely prevent blood clots (venous thromboembolism) in people newly diagnosed with grade 4 glioma, a serious brain cancer. About 40 adults will take apixaban while undergoing standard radiation and chemotherapy. The main goa…

This study is testing a program called FearLess to see if it helps people with brain tumors and their caregivers deal with the fear of the cancer coming back. The researchers want to find out if the study methods work well, including how they recruit participants and keep them in…