AORTIC VALVE DISEASE

This study is testing a device called a valved graft for people who need surgery to replace a heart valve or repair the main artery (aorta). About 260 participants will receive the device and be followed to see how well it works and if it is safe. The main goals are to measure su…

This study is testing a new, less invasive heart valve implant for people with severe aortic regurgitation (a leaky heart valve). The goal is to see if this implant can reduce the risk of death, stroke, or repeat hospital visits compared to standard care. About 210 adults with se…

This study tests a new way to replace the aortic valve in 50 people who have a mechanical heart pump (LVAD) and a leaky aortic valve. The procedure uses a special valve system inserted through a tube in the artery, aiming to fix the leak without open-heart surgery. The goal is to…

This study follows 225 adults undergoing the Ross procedure, a surgery that replaces a diseased aortic valve with the patient's own pulmonary valve. Researchers will track survival, re-hospitalization, and need for repeat surgeries over 1, 5, and 10 years. The goal is to confirm …

This study explores whether a portable device that measures chest vibrations from heartbeats can diagnose aortic valve disease and aortic aneurysms. Researchers will compare readings from 180 adults with and without these conditions. The goal is to develop a non-invasive, easy-to…

This study is collecting information from 500 people who need a new aortic valve to see how the INSPIRIS RESILIA valve performs in real life. Researchers will measure blood flow through the valve and check for leaks using heart ultrasounds over time. The goal is to understand how…

This study watches which guidewires doctors use during a TAVI procedure, a minimally invasive heart valve replacement. Researchers want to see if a newer wire, the SavvyWire, works better than standard wires. About 300 people aged 50 or older having a TAVI through the groin will …

This study is for people who develop a new type of heart block (left bundle branch block) after having a TAVI procedure to replace their aortic valve. Researchers want to see how often dangerous heart rhythm problems occur and whether a small, implantable heart monitor can detect…

This study is following 10,000 adults with heart valve disease to learn how the condition changes over time. Researchers will use scans and tests to track disease progression and see how treatments like surgery, medications, or lifestyle changes may affect outcomes. The goal is t…