ALZHEIMER'S DISEASE (AD)

This early-stage study tests if a new microsurgery on the neck is safe for people with Alzheimer's disease. The surgery aims to create a detour for the brain's drainage system to help remove harmful protein buildup. Researchers will monitor 35 participants for side effects and ch…

This early-stage study tests a new drug called 8M2D for the first time in people. The goal is to see if it is safe and tolerable in healthy adults (ages 18-55) and in people with early Alzheimer's disease. Researchers will also check if the drug can lower amyloid beta, a protein …

This study will check if measuring a specific form of the protein alpha-synuclein in spinal fluid can reliably tell apart Lewy body dementia from Alzheimer's disease. About 286 adults aged 50 and older with signs of either condition will provide a spinal fluid sample for analysis…

This early-stage study tests a single injection of a new drug called QLH2405 in 68 healthy volunteers and people with mild memory problems or mild Alzheimer's disease. The main goal is to check if the drug is safe and how the body processes it. This is a first step to see if the …

This study will test whether 8 weeks of improvisation music therapy can improve mood and lower stress for people with mild Alzheimer's disease and their care partners. About 40 older adults and their caregivers will attend music sessions and fill out questionnaires before and aft…

This study tests whether playing specific sounds during deep sleep can improve memory and lower a key Alzheimer's protein (p-tau217) in people with mild cognitive impairment (MCI). About 114 participants, including those with MCI and healthy older adults, will have their sleep mo…