ALCOHOLISM

This study tests whether tirzepatide (Mounjaro), a drug used for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. Researchers will give 108 participants either tirzepatide or a placebo for 16 weeks and track changes in heavy drink…

This Phase 2 trial tests whether adding cannabidiol (CBD) to standard naltrexone treatment can reduce alcohol cravings in people with alcohol addiction. 150 participants will receive either a high or low dose of CBD plus naltrexone, or a placebo plus naltrexone, for 14 days. The …

This study tests whether a single dose of ketamine, combined with real-time brain training (neurofeedback), can help people with alcohol use disorder drink less. 75 participants will receive either ketamine or placebo, plus real or fake neurofeedback. The goal is to see if the co…

This study tests whether offering specialized alcohol use disorder treatment right in the liver clinic helps people newly diagnosed with alcohol-related liver disease stop drinking. About 221 participants will either get this offer plus standard care, or standard care alone. The …

This study tests whether a monthly injection of naltrexone (a medication that blocks alcohol's rewarding effects) helps people who drink for pleasure reduce heavy drinking more than a placebo. About 60 adults with alcohol use disorder who drink heavily will receive either the sho…

This study tests a device that uses magnetic pulses to stimulate the brain (Deep TMS) to help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will get either real or fake (sham) treatment over several weeks. The goal is to see if the re…

This study looks at how well a combined recovery program and home telehealth support help veterans with alcohol or drug problems. About 195 veterans in a VA inpatient unit will take part. The goal is to see if these extra services reduce substance use and improve recovery compare…

This study aims to find risk factors for depression and other mental health issues in medical students. Researchers will follow up to 10,000 students for up to 12 years each, using yearly questionnaires. The goal is to compare those who enter medical school with those who do not,…

This study looks at why a single dose of ketamine works better for some people with hard-to-treat depression. Researchers will use brain scans to measure brain chemicals in 60 adults, comparing those with and without a family history of alcohol use disorder. The goal is to find o…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. Up to 1,000 adults aged 18 and older will participate in a single visit. No trea…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with and without alcohol use disorders. Researchers will use MRI scans to see how the brain works during these tasks. The goal is to develop better tools for future st…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce these behaviors and improve quality of life. About 130 English-speaking adults with bipol…

This study aims to build a large data repository by gathering information from 10,000 adults who have used alcohol or drugs in the past 30 days. Participants will use a smartphone app that collects data like app usage and movement, and complete daily and monthly surveys about moo…