ALCOHOLIC HEPATITIS

This study tests whether adding N-acetylcysteine (NAC) to standard steroid treatment helps people with severe alcoholic hepatitis live longer and have fewer complications. About 390 adults aged 18-75 with a high Maddrey score will be enrolled. The main goal is to see if the combi…

This early-phase trial is testing whether a form of hyaluronic acid called HA35 can help prevent muscle loss in people with alcoholic hepatitis. 54 participants will take either HA35 or a placebo capsule daily for 90 days. The study involves two in-person visits with muscle biops…

This study tests whether giving a longer course of steroids or adding N-acetylcysteine can improve survival and liver health in people with severe alcoholic hepatitis. About 477 adults with severe liver inflammation from heavy drinking will be enrolled. The goal is to see if thes…

This study tests whether starting alcohol treatment soon after a liver transplant helps people with severe alcoholic hepatitis stay sober and live longer. About 200 participants will receive either standard care or a combined person- and computer-delivered alcohol program. The go…

This study tests whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) for 6 months can help people with alcohol use disorder reduce heavy drinking and improve liver health. Researchers will compare the probiotic to a placebo in 60 adults who drink heavily. The goal …

This study looks at how immune cells (called PBMCs) work in three groups: healthy people, heavy drinkers, and patients with alcoholic hepatitis. Researchers will collect a blood sample to measure cell energy, inflammation, and metabolism. The goal is to better understand why some…

This study looks at bacteria found in the liver, blood, and stool of 50 people with severe alcoholic hepatitis. Researchers want to see if these bacteria are linked to how well patients respond to treatment and their overall survival. The goal is to find new ways to treat this se…