ADVANCED COLORECTAL CANCER

This study tests whether a combination of three drugs (avutometinib, defactinib, and cetuximab) can help control advanced colorectal cancer that no longer responds to standard treatments. About 33 adults with unresectable, anti-EGFR-refractory cancer will participate. The main go…

This study tests a new drug called TL938 combined with trastuzumab in people with HER2-positive colorectal cancer that has spread or come back and cannot be removed by surgery. About 80 adults who have already tried several standard treatments will receive the combination to find…

This early-stage study tests a new drug called CBI-1214 in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 80 participants will receive the drug through an IV, and r…

This study is testing whether a combination of three drugs (irinotecan liposome, capecitabine, and enlansubemab) given alongside a short course of radiation can shrink advanced rectal cancer before surgery. The goal is to see if the cancer disappears completely or is greatly redu…

This study tests an experimental drug called RBS2418 in people with advanced colorectal cancer that has spread and is no longer responding to standard treatments. The drug works by helping the body's immune system recognize and attack cancer cells. About 150 adults will receive e…

This study tests a new first-line treatment for people with advanced colorectal cancer that cannot be removed by surgery or has spread. The treatment combines two drugs, levozolinate and 5-FU, given together through an IV. The goal is to see if this approach helps control the can…

This early-phase study tests a new experimental drug called BGB-53038 in people with advanced or metastatic solid tumors that have a specific genetic change (KRAS mutation or amplification). The drug is a pan-KRAS inhibitor, meaning it aims to block many forms of the faulty KRAS …

This study is testing whether using a blood test (liquid biopsy) to monitor treatment response can help people with advanced colorectal cancer maintain a better quality of life. About 150 adults starting their first treatment will be randomly assigned to have their care guided by…