ADVANCED BREAST CANCER

This study tested the safety of combining two drugs, alpelisib and fulvestrant, in 40 men and post-menopausal women with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has a PIK3CA mutation and has stopped responding to hormone therapy. The goal was to…

This early-phase study tested a new daily pill called TQB3616 in 40 adults with advanced breast cancer that had stopped responding to standard hormone therapy. The drug aims to slow or stop cancer cell growth. The main goals were to find a safe dose and understand how the body pr…

This early-phase trial tested a combination of three drugs—olaparib, palbociclib, and fulvestrant—in 9 people with advanced, hormone receptor-positive breast cancer who also have BRCA1 or BRCA2 mutations. The main goal was to see if the combination is safe and to measure how long…

This study looked at how the drug palbociclib works in the body of Chinese women with a certain type of advanced breast cancer (ER+, HER2-). 26 postmenopausal women took the drug to measure its levels and check for side effects. The goal was to gather information needed for Chine…

This early-stage trial tested a new drug called CyPep-1, injected directly into tumors, combined with the immunotherapy pembrolizumab. It included 6 adults with advanced head and neck cancer, melanoma, or triple-negative breast cancer that had spread. The goal was to see if the c…

This study looked at whether group-based cancer rehabilitation (exercise and support) works when done online versus in person for people with advanced breast or colorectal cancer. 111 adults took part in Toronto and Vancouver. The goal was to see if the virtual option is practica…

This study looked at health records from nearly 4,000 women with advanced breast cancer to see if they could recreate the findings of an earlier clinical trial called MONARCH-3. The goal was not to test a new treatment, but to learn whether real-world data can be trusted to answe…

This study looked at whether information from routine medical records (real-world data) can produce the same findings as a controlled clinical trial for advanced breast cancer. Researchers analyzed data from over 2,400 patients to see if they could replicate the results of the MO…

This study looked at whether information from routine medical care (real-world data) can produce the same results as a traditional clinical trial for advanced breast cancer. Researchers analyzed data from over 6,000 patients in large health databases. The goal is to learn when re…