ADRENOCORTICAL CARCINOMA

This study tests a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 100 adults with rare cancers of the urinary or reproductive systems. The goal is to see if the drugs can shrink tumors and control the disease. Participants have cancers that cannot be removed…

This study tests a treatment for a rare and aggressive adrenal cancer that has spread to the lining of the abdomen. About 30 people will have surgery to remove all visible tumors, followed by heated chemotherapy (HIPEC) delivered directly into the abdomen. The goal is to see if t…

This study tests a drug called pembrolizumab, which helps the immune system fight cancer, in people with advanced adrenocortical carcinoma (a rare adrenal gland cancer) that cannot be removed by surgery. The goal is to see if the drug can shrink or control the tumors. About 39 pa…

This study tests a combination of two drugs, pembrolizumab and lenvatinib, in people with advanced adrenal cortical carcinoma that has not responded to standard chemotherapy. The goal is to see if this treatment can shrink or control the cancer. About 30 adults will take part, re…

This study is a first step toward creating an immunotherapy for adrenocortical carcinoma, a rare and aggressive adrenal gland cancer. Researchers are analyzing blood and tumor samples from 150 people (patients and healthy volunteers) to find the right targets for a future vaccine…

This study looks back at medical records from about 1,000 people with adrenocortical carcinoma (ACC), a rare and serious adrenal gland cancer. Researchers want to see how factors like age, sex, race, and how much cancer is present affect survival and how well treatments work. No …