ADRENAL INSUFFICIENCY

This study tests whether taking extra hydrocortisone during stressful times (like illness or emotional strain) improves quality of life, especially fatigue, in people with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA). Participants are 50 or older, on low-dose predni…

This study will measure cortisol in saliva from 220 healthy adults to establish normal reference ranges. Researchers will also determine the best cut-off values to diagnose Cushing's syndrome and adrenal insufficiency. The goal is to improve accuracy and ease of testing for these…

This study aims to find the most accurate cortisol levels to diagnose adrenal insufficiency, a condition where the body doesn't make enough cortisol. Researchers will test 90 healthy volunteers and people already diagnosed with the condition using a new, more specific cortisol as…

This study tests whether a low-dose hormone called hydrocortisone can relieve symptoms like fatigue and dizziness in people who have recently stopped taking steroids for giant cell arteritis or polymyalgia rheumatica. About 100 adults aged 50 and older will receive either hydroco…

This study aims to learn more about hormone and metabolism disorders in children by examining their genes. Up to 15,000 children aged 3 months to 18 years with known or suspected endocrine or metabolic conditions, along with their family members, will participate. Researchers wil…

This study looks at how often children treated for leukemia or lymphoma develop a shortage of natural stress hormones (cortisol) after high-dose steroid therapy. About 40 children will be followed with simple hormone tests during their hospital stays. The goal is to learn how com…

This study looks at how often the adrenal glands stop working properly after surgery in patients with primary aldosteronism (a cause of high blood pressure) who may also have extra cortisol production. About 521 adults who had one adrenal gland removed will be followed to see if …

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…