ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Clinical trials for ACUTE-ON-CHRONIC LIVER FAILURE (ACLF) explained in plain language.
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Pig liver machine offers hope for liver failure patients
Disease control Not yet recruitingThis early-stage study tests a new approach to support people with acute-on-chronic liver failure, a life-threatening condition where the liver suddenly stops working. The treatment uses a genetically-modified pig liver connected to a special machine that cleans the blood outside…
Matched conditions: ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Phase: PHASE1 • Sponsor: eGenesis, INC • Aim: Disease control
Last updated May 26, 2026 07:59 UTC
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New liver support method aims to boost recovery in severe liver failure
Disease control Not yet recruitingThis study tests whether a combination of blood filtering (hemoadsorption) and half-dose plasma exchange can help adults with acute-on-chronic liver failure (ACLF) recover or stay stable until a liver transplant. About 240 participants will receive either this liver support proto…
Matched conditions: ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Phase: NA • Sponsor: Unidade Local de Saude do Nordeste • Aim: Disease control
Last updated May 26, 2026 07:52 UTC
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New blood filter could give liver patients a lifeline
Disease control Not yet recruitingThis study tests a blood filtering treatment called DPMAS for people with acute-on-chronic liver failure, a sudden worsening of chronic liver disease that can be life-threatening. About 56 adults will be randomly assigned to receive either standard care alone or standard care plu…
Matched conditions: ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Phase: NA • Sponsor: Institute of Liver and Biliary Sciences, India • Aim: Disease control
Last updated May 26, 2026 07:27 UTC
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Can vitamin c save kidneys in liver failure patients?
Disease control Not yet recruitingThis study tests whether adding vitamin C to standard treatment can help patients with severe liver disease (ACLF) who have a serious infection (septic shock) and kidney injury. Vitamin C is a safe, cheap antioxidant that may reduce inflammation and protect the kidneys. The study…
Matched conditions: ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Phase: NA • Sponsor: Institute of Liver and Biliary Sciences, India • Aim: Disease control
Last updated May 18, 2026 12:08 UTC
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Liver dialysis breakthrough? new device could save lives in severe liver failure
Disease control Not yet recruitingThis study tests a device called DIALIVE 2.0, which acts like a dialysis machine for the liver, in people with acute-on-chronic liver failure (ACLF) grades 2-4. About 72 adults aged 18-70 with liver cirrhosis and recent worsening will either receive standard care or standard care…
Matched conditions: ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Phase: PHASE3 • Sponsor: Yaqrit Ltd • Aim: Disease control
Last updated May 18, 2026 11:59 UTC