ACUTE ON CHRONIC LIVER FAILURE (ACLF)

This is a first-in-human safety study testing a new temporary liver support system for people with a sudden, severe worsening of chronic liver failure. The system connects a patient's blood to a genetically engineered pig liver outside their body using a special machine, aiming t…

This study is testing a device called DIALIVE 2.0, which works like dialysis for the liver. It aims to help people with sudden, severe liver failure on top of long-term liver disease by filtering toxins from their blood and replacing a key protein. The trial will compare the devi…

This early-stage study will test whether injecting lab-grown liver-like cells into the abdominal muscle is safe for people with severe liver failure. Researchers will enroll 24 patients to check for side effects and see if the treatment helps improve survival. The main goal is to…

This study is testing if adding Vitamin C to standard hospital care helps patients with severe, sudden liver failure who also have a dangerous infection and kidney injury. About 110 very sick patients will be randomly assigned to receive either standard treatment alone or standar…

This study is testing a special blood filtering treatment for people with a sudden, severe worsening of chronic liver failure. About 56 patients will be randomly assigned to receive either standard medical care alone or standard care plus the filtering treatment. The main goal is…