ACUTE CORONARY SYNDROME

This phase 3 trial tests whether the drug dalcetrapib can reduce the risk of major heart problems like heart attacks in people who have a specific genetic makeup (AA genotype) and have recently had a heart-related event. About 2,000 participants will receive either dalcetrapib or…

This pilot study is testing whether the drug colchicine can reduce artery plaque in 120 heart attack survivors who have a specific gene change (TET2). Participants take colchicine or standard care for 12 months. The goal is to see if this gene change can guide personalized treatm…

This study tests whether a new pressure microcatheter works as well as the standard pressure wire for guiding stent placement in people with coronary artery disease. About 2,500 participants will be randomly assigned to one of the two devices during their procedure. The main goal…

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This study looks at 2,600 adults who have had a heart attack, received stents, and also have an H. pylori stomach infection. These patients take blood thinners that raise their risk of stomach bleeding. The trial compares a newer drug (vonoprazan plus amoxicillin) against a stand…

This study compares a two-drug combination (dabigatran and ticagrelor) against the standard three-drug therapy (dabigatran, clopidogrel, and aspirin) in about 1,200 adults with atrial fibrillation who recently had a stent placed after a heart attack. The goal is to see if the two…

This study tests a new, noninvasive device that uses ultra-sensitive magnetocardiography to detect heart attacks. Researchers will enroll nearly 4,000 healthy volunteers and chest pain patients to see if this magnetic scan can identify heart damage more accurately than current me…

This study tests a 12-week program that combines positive psychology (building well-being) with motivational interviewing (boosting exercise drive) to help 280 heart attack survivors who are not very active. Participants do weekly activities and phone sessions with a coach, plus …

This study tests a digital lifestyle platform designed to support patients after they leave inpatient rehabilitation. It includes people recovering from COPD, heart attacks, fractures, or minor strokes. The goal is to see if the platform is easy to use, acceptable, and helps pati…

This study is creating a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic, biochemical, and molecular data to understand how symptoms and disease patterns may vary among women. The goal is to identify subtypes of heart disease…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…