Vision disorder

This trial tests the long-term safety of an experimental medicine called ultevursen, given as an injection into the eye, for people with retinitis pigmentosa caused by mutations in a gene called USH2A. The study enrolls about 81 adults and children who completed a previous 24-mon…

This study tests a caregiver-led digital program called VIPPSTAR designed to improve vision and brain development in infants at risk of or with visual impairment. The program provides personalized activities integrated into daily routines, supported by remote coaching. Researcher…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This study tests a 3-week digital program delivered through the VIPPSTAR app, designed to help children and adolescents with visual impairment build a healthier body image and become more critical of social media content. Participants aged 10-18 will complete daily exercises and …

This study tests a 12-week adapted physical activity program for children and adolescents aged 10-17 with visual impairment. The program includes supervised school-based exercise sessions and home-based activities, along with peer-group meetings to promote social inclusion. Resea…

This study explores how visual impairment affects movement and daily activities, and tests a wearable system called VIS4ION that provides audio and touch cues to help users navigate. Researchers will enroll 150 adults with visual impairment and healthy controls to see if the devi…

This clinical trial tests whether transcranial magnetic stimulation (TMS) can restore vision in adults with severe retinal degeneration. Over 100 participants will receive either real TMS or a sham (fake) treatment for five days, and their eyesight will be checked up to a year la…

This study looks at whether taking a daily supplement of lutein, zeaxanthin, and meso-zeaxanthin (natural pigments found in plants) can improve contrast sensitivity—the ability to see subtle differences in light and dark—in healthy Chinese adults aged 35 and older. Over 12 months…

This project at King's College London asks how hospital outpatient departments can work better for people with neurofibromatosis who also have sensory challenges. About 30 patients, carers, and staff from Guy's and St Thomas' NHS Foundation Trust take part in interviews, observat…

This study investigates whether computerized cognitive training can change brain metabolism and excitatory/inhibitory balance in adults with schizophrenia. Participants will undergo brain imaging and EEG before and after about 10 hours of either perceptual discrimination or cogni…

This study surveys about 2,800 adults aged 65 and older in Xinxing County, China, to measure how many have untreated vision or hearing problems. Participants receive eye exams, hearing tests, and questionnaires. The goal is to provide local health services with data to improve ca…

This study will see if setting up vision centers in rural South Asian communities helps more people get the eye care they need. Researchers will compare communities that get a vision center right away with those that wait. They will check if more people get glasses and if their e…

This observational study will compare dental caries (tooth decay) experiences and quality of life between visually impaired and sighted children aged 6 to 14. Researchers will use a special questionnaire to measure how cavities affect daily life, and will also count decayed, miss…

This study will see if outdoor activities like rafting, canyoning, and kayaking can help teens with and without disabilities feel more included and connected. About 35 teens aged 12–16 will take part, with some doing the activities and others not. Researchers will measure changes…

This study will look at what happens when a standalone eye center becomes part of a government hospital in Kalaiya, Nepal. Researchers will track changes in how many patients visit, follow up, and get referrals, and ask patients and staff what they think. The goal is to learn if …

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…