Vasculitis
MONDO:0018882Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behcet disease) to relatively minor skin disease.
Also known as: systemic vasculitis, angiitis
286 clinical trials for this condition and its sub-types, 63 tagged with Vasculitis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Vasculitis
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Necrotizing vasculitis 0 trials · 143 incl. sub-types
3 sub-types
- Anti-neutrophil cytoplasmic antibody-associated vasculitis 82 trials · 130 incl. sub-types Sub-types →
- Immunoglobulin A vasculitis 16 trials
- Disseminated visceral giant cell angiitis 0 trials
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Arteritis 5 trials · 104 incl. sub-types
7 sub-types
- Granulomatous angiitis 0 trials · 52 incl. sub-types Sub-types →
- Microscopic polyangiitis 34 trials
- Takayasu arteritis 27 trials
- Polyarteritis nodosa 7 trials · 9 incl. sub-types Sub-types →
- Cerebral arteritis 0 trials
- Endarteritis 0 trials
- Juvenile temporal arteritis 0 trials
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Central nervous system vasculitis 3 trials · 55 incl. sub-types
5 sub-types
- Temporal arteritis 52 trials Sub-types →
- Primary central nervous system vasculitis 2 trials Sub-types →
- Benign angiitis of the central nervous system 0 trials
- Central nervous system AIDS arteritis 0 trials
- Cerebral arteritis 0 trials
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Phlebitis 13 trials · 21 incl. sub-types
1 sub-type
- Thrombophlebitis 6 trials · 9 incl. sub-types Sub-types →
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Immune complex mediated vasculitis 0 trials · 18 incl. sub-types
5 sub-types
- Immunoglobulin A vasculitis 16 trials
- Cryoglobulinemic vasculitis 4 trials Sub-types →
- Hypocomplementemic urticarial vasculitis 2 trials
- Cutaneous leukocytoclastic angiitis 1 trial
- Erythema elevatum diutinum 0 trials
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Hypersensitivity vasculitis 0 trials · 16 incl. sub-types
2 sub-types
- Immunoglobulin A vasculitis 16 trials
- Allergic cutaneous vasculitis 1 trial
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Kawasaki disease 15 trials
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Cutaneous vasculitis 4 trials · 5 incl. sub-types
1 sub-type
- Allergic cutaneous vasculitis 1 trial
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Deficiency of adenosine deaminase 2 3 trials
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Retinal vasculitis 2 trials
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Aortitis 1 trial
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Livedoid vasculopathy 1 trial
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Choroiditis 0 trials · 1 incl. sub-types
4 sub-types
- Serpiginous choroiditis 1 trial
- Infectious posterior uveitis 0 trials
- Multifocal choroiditis 0 trials Sub-types →
- Paraneoplastic uveitis 0 trials
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Secondary vasculitis 0 trials · 1 incl. sub-types
2 sub-types
- Drug-induced vasculitis 1 trial
- Postinfectious vasculitis 0 trials
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Shwartzman phenomenon 0 trials
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Autoimmune vasculitis 0 trials
1 sub-type
- Rheumatoid vasculitis 0 trials
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Lymphangitis 0 trials
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Vasculitis, lymphocytic, nodular 0 trials
Most studied deeper sub-types
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Could a One-Time immune cell treatment tame severe vasculitis?
Disease control OngoingThis Phase 2 trial tests a one-time infusion of rapcabtagene autoleucel, a CAR-T cell therapy made from a patient's own immune cells, against standard treatments for severe active granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA). About 126 adults aged 18-7…
Phase 2 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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New hope for kids with rare blood vessel disease: avacopan trial launches
Disease control OngoingThis study tests whether the drug avacopan can help children aged 6 to 18 with a rare autoimmune disease called ANCA-associated vasculitis, which causes inflammation of blood vessels. About 20 participants will receive avacopan alongside standard treatments like rituximab or cycl…
Phase 3 • Sponsor: Amgen • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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New drug shows promise for rare blood vessel disease
Disease control OngoingThis study tests a drug called tezepelumab in 42 adults with EGPA, a rare disease that causes inflammation in blood vessels and can damage organs. The goal is to see if the drug helps patients reach remission, meaning no active disease and low steroid use. Participants receive ei…
Phase 2 • Sponsor: Imperial College London • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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New hope for long COVID heart sufferers: drug combo trial launches
Disease control OngoingThis study tests whether a combination of anti-inflammatory and heart-protecting drugs can reduce symptoms and heart damage in people with Long COVID who have ongoing heart inflammation. About 279 adults with heart inflammation seen on MRI will receive either the drug combo or a …
Phase 3 • Sponsor: Valentina Puentmann • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Experimental Donor-Cell therapy takes aim at tough autoimmune diseases
Disease control OngoingThis early-stage study tests a therapy called SC291, made from donor immune cells, in 7 people with severe lupus or vasculitis that hasn't improved with standard treatments. The goal is to see if it is safe and tolerable, and to get a first look at whether it can control the dise…
Phase 1 • Sponsor: Sana Biotechnology • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Shingles vaccine trial aims to protect vulnerable patients
Prevention OngoingThis study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a s…
Phase 4 • Sponsor: University of Sao Paulo General Hospital • Aim: Prevention
Last updated Jun 27, 2026 12:29 UTC
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New blood test could spot autoimmune diseases earlier
Knowledge-focused By invitation onlyThis study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …
Sponsor: Peking University People's Hospital • Aim: Knowledge-focused
Last updated Aug 28, 2026 00:00 UTC
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Rare disease pregnancy study pulled before it began
Knowledge-focused CancelledThis study was designed to track pregnancies in women with rare autoimmune and systemic diseases to understand complications and improve care. It planned to enroll women with conditions like lupus, rheumatoid arthritis, and scleroderma. However, the study was withdrawn before any…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC