Vascular ectasia

This study tests whether a rapamycin cream, applied after laser treatment, can improve the appearance of port wine stain birthmarks in children aged 10 and under. Thirty participants will receive laser therapy plus either a low or high dose of the cream or a placebo cream for 12 …

This phase 2 trial tests the drug everolimus in 67 people with vascular anomalies (abnormal blood vessels) that haven't responded to standard treatments. The goal is to shrink the lesions and improve symptoms. Participants take everolimus daily for 6 months, with doses adjusted b…

This early-phase trial tests a new nasal ointment called TOR-582, which contains sirolimus, in 27 adults with hereditary hemorrhagic telangiectasia (HHT) who have frequent nosebleeds. Participants apply the ointment inside their nostrils twice daily for 12 weeks, with different s…

This study tests whether adding epinephrine to a glycerin and lidocaine mixture improves the treatment of small leg veins (telangiectasias). Twenty adults will have one leg treated with the standard mixture and the other with the mixture plus epinephrine. Doctors will rate vein c…

This study tests whether taking daily supplements containing collagen, MSM, and vitamin C for 16 weeks can reduce facial redness and spider veins in healthy women aged 35–65. Ninety participants with stable facial redness will be randomly assigned to one of two supplement doses o…

This study will test a special laser called the Vbeam Pro on 40 adults with rosacea or port-wine stain birthmarks. The goal is to see if the laser can safely clear or improve these red skin conditions. Participants will receive laser treatments and be evaluated for changes in app…

This study looks at how hereditary hemorrhagic telangiectasia (HHT) affects the quality of life of children and young adults aged 2 to 25. Participants will fill out questionnaires about their physical, emotional, and social well-being. Researchers will also review medical record…