Varicose disease

This study tests whether shining a special low-level laser on chronic leg ulcers can help them heal faster. 96 adults with venous leg ulcers will receive either real laser treatment plus standard compression, or a sham laser plus compression, twice a week for 16 weeks. The goal i…

This study tests whether adding a laser to standard foam treatment works better for varicose veins. About 102 adults with small-to-medium leg veins will get either foam alone or foam plus a laser. The main goal is to see if the vein closes up more often after 30 days, with fewer …

This study tests two different laser wavelengths (1470 nm and 1940 nm) for a procedure called laser crossectomy to treat varicose veins. The goal is to see which wavelength better prevents vein reflux from returning at the groin junction, while also checking for pain and side eff…

This study tests whether giving blood-thinning medicine after varicose vein surgery can prevent dangerous blood clots in the legs or lungs. About 1 in 50 people develop a clot after these procedures. The trial will enroll 3,175 adults and compare those who receive the medicine to…

This study tests a specially designed nursing program for people recovering from varicose vein surgery. The program focuses on teaching patients how to manage their own recovery, including daily activities and medical care. Researchers will measure whether this approach improves …

This study compares two treatments for varicose veins: foam sclerotherapy (injecting a foam to close the vein) and mechanochemical ablation (using a device and medication). Both are done with local anesthesia and allow quick recovery. 50 patients will be randomly assigned to one …

This study compares two laser wavelengths (1470 nm and 1940 nm) for treating varicose veins in the legs. About 280 participants will receive one of the two laser treatments and be followed for five years. The goal is to see if the newer 1940 nm wavelength works as well as the sta…

This study tests a device that delivers oxygen to chronic leg ulcers caused by vein problems. About 212 adults will get either the real oxygen therapy or a sham treatment, along with standard compression bandages, for up to 16 weeks. The main goal is to see if the oxygen therapy …

This study is observing 400 people aged 12 and older who have noncirrhotic portal hypertension (NCPH) or are at risk for it. NCPH is a liver condition that increases blood pressure in the liver's blood vessels without causing cirrhosis, and often has no early symptoms. Researcher…

This registry follows 10,000 people with early varicose veins to see how chronic venous disease develops and worsens over time. Researchers will track signs like spider veins, swelling, skin changes, and blood clots using yearly checkups and ultrasound scans. The goal is to bette…

This study looks at whether people with hemorrhoids are more likely to have varicose veins in their legs. Researchers will use ultrasound to check the leg veins of 400 adults—200 with hemorrhoids and 200 without. No treatments or procedures are given; the goal is simply to see if…

This study aims to validate the Caprini score, a tool that estimates blood clot risk, in 3,000 people undergoing varicose vein surgery. Participants will be followed for four weeks after procedures like laser treatment or vein stripping to see if the score accurately predicts who…

This observational study looks at the best time to take infrared images of varicose veins after a person stands up from lying down. Researchers will take pictures every 5 seconds for 3 minutes in 20 patients with varicose veins. The goal is to improve imaging techniques for bette…