New laser wavelength may offer smoother varicose vein treatment

NCT ID NCT05663359

Symptom relief Sponsor: Clinique Pasteur Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two laser wavelengths (1470 nm and 1940 nm) for treating varicose veins in the legs. About 280 participants will receive one of the two laser treatments and be followed for five years. The goal is to see if the newer 1940 nm wavelength works as well as the standard 1470 nm one, while possibly reducing pain and complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: endovenous laser ablation (EVLA) at 1940 nm or 1470 nm
What this could lead to: If successful, this could show that a newer laser wavelength works just as well as the standard one while causing less pain or fewer side effects.
What could go wrong: This is a relatively small, early-stage comparison study. The newer wavelength may not prove superior, and individual results can vary. Long-term benefits are not yet established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 280 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2023

Expected to finish

Feb 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Primary insufficiency of the great saphenous vein (GSV) and/or small saphenous vein (SSV) * Patient candidate for endothermic treatment of the lower limbs * CEAP: C2 - C6 * Patient with a target vein diameter (GSV and/or SSV) \>= 3 mm throughout the target vein segment * Patient affiliated or beneficiary of a social security scheme * Patient having signed the informed consent Exclusion Criteria: * Patient with a current serious pathology and/or a life expectancy of less than 5 years * Patient who has had a deep or superficial vein thrombosis in the previous 6 months * Obliterating arteriopathy of the lower limb concerned, with an IPS \< 0.8 or \> 1.3 * Patient with post-thrombotic obstructive syndrome at the popliteal and/or femoral and/or iliac stage on the ipsilateral lower limb * Patient with primary or post-thrombotic axial deep venous reflux on the ipsilateral lower limb * Suspicion of non-post-thrombotic iliac compression on echo-doppler * Contraindication to the planned treatment technique * Patient whose geographical distance is not compatible with the follow-up of the study * Pregnant or breastfeeding women * Patient linguistically or psychologically unable to understand the information given, to give informed consent or to answer the study questionnaires. * Protected patients: Adults under guardianship, or other legal protection; Hospitalized without consent.

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Conditions

The condition(s) this trial relates to.

varicose disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Varicose veins

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

New laser wavelength may offer smoother varicose vein treatment

What the study statuses mean