Univentricular heart
MONDO:0015451Univentricular heart (UVH) is a severe congenital cardiac malformation characterized by both atria related entirely or almost entirely to one functionally single ventricular chamber. The clinical manifestations include congestive heart failure, failure to thrive, cyanosis, hypoxemia and neurodevelopmental disabilities.
Also known as: Double inlet left ventricle
23 clinical trials for this condition and its sub-types, 21 tagged with Univentricular heart itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Univentricular heart
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Can a common diuretic protect the liver and heart in children born with one heart chamber?
Disease control CompletedThis trial investigates how the Fontan surgery, which reroutes blood flow in children born with a single heart ventricle, affects the liver and heart. Researchers use MRI scans and blood tests to measure fibrosis (scarring) and lymphatic congestion. They also test whether spirono…
Phase 1/2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Home workouts boost fitness in kids with single ventricle hearts
Symptom relief CompletedThis study tested whether a live-video-supervised exercise program could improve fitness in children and teens (ages 8-19) born with a single ventricle, a condition often treated with the Fontan procedure. Participants exercised three times a week for three months, then a mainten…
Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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Researchers study digoxin dosing in infants with rare heart condition
Knowledge-focused CompletedThis study looks at how the heart medication digoxin is processed in infants born with single ventricle heart disease. Researchers will collect blood samples during routine care to measure drug levels. The goal is to better understand dosing, but the study does not change the inf…
Phase 1/2 • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC
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Mini heart monitor implanted in newborns to track dangerous rhythms
Knowledge-focused CompletedThis study looked at whether a small device called an implantable loop recorder can be safely placed in newborns who have only one working heart chamber. Ten babies received the monitor during their first heart surgery. The goal was to see if the device could continuously track h…
Early phase 1 • Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC