Univentricular cardiopathy

This trial investigates how the Fontan surgery, which reroutes blood flow in children born with a single heart ventricle, affects the liver and heart. Researchers use MRI scans and blood tests to measure fibrosis (scarring) and lymphatic congestion. They also test whether spirono…

This study tested whether injecting a child's own heart stem cells during a planned surgery could help their heart work better. It involved 25 children with hypoplastic left heart syndrome, a condition where the left side of the heart is underdeveloped. The main goals were to see…

This study looked at the long-term safety of udenafil in 301 adolescents with single ventricle heart disease who had Fontan surgery. Participants took the drug for 52 weeks. The main goal was to track side effects, with secondary measures including exercise capacity and blood ves…

This study tested whether the drug udenafil can reduce liver stiffness in 88 children with single ventricle heart disease, a condition where the heart has only one pumping chamber. Participants took udenafil twice daily for 52 weeks, and liver stiffness was measured using ultraso…

This study tests a two-part virtual program for teens aged 13-18 with Fontan physiology, a type of single-ventricle heart disease. The first part is a small-group wellness education session each week for 5 weeks, led by a psychologist. The second part is a personalized home exerc…

This study tested whether a live-video-supervised exercise program could improve fitness in children and teens (ages 8-19) born with a single ventricle, a condition often treated with the Fontan procedure. Participants exercised three times a week for three months, then a mainten…

This study looks at how the heart medication digoxin is processed in infants born with single ventricle heart disease. Researchers will collect blood samples during routine care to measure drug levels. The goal is to better understand dosing, but the study does not change the inf…

This study looked at whether a small device called an implantable loop recorder can be safely placed in newborns who have only one working heart chamber. Ten babies received the monitor during their first heart surgery. The goal was to see if the device could continuously track h…

This study tested whether 3D-printed heart models or augmented reality (AR) help first-year medical students understand two rare heart defects better than traditional slide lectures. 26 students took a quiz before and after learning with one of the three methods. The goal was to …