Ulcer disease

Researchers are testing whether muffins enriched with pomegranate peel powder can help people with stomach ulcers caused by H. pylori infection. The trial gives participants either a regular whole wheat muffin or one with 1.5 or 3 grams of pomegranate peel powder, alongside their…

This early-stage trial is testing whether a single topical application of FGF-1, a protein that helps cells grow, is safe for people with diabetic or venous stasis ulcers. The study enrolls a small group of adults with full-thickness leg ulcers that have lasted at least 8 weeks. …

This trial tests whether adding vacuum compression therapy — a device that applies cycles of pressure and suction to the leg — can improve healing of chronic lower limb ulcers. Adults with ulcers that have not healed despite standard care will receive either standard wound care a…

This trial tests whether adding supervised exercise to standard care can improve wound healing in people with diabetic foot ulcers. Participants are randomly assigned to aerobic exercise, a structured exercise protocol, or standard care alone for 12 weeks. Researchers track ulcer…

This study tested whether sildenafil (the drug in Viagra) can help heal painful finger ulcers in people with scleroderma, a disease that damages blood vessels. 84 participants took either sildenafil or a placebo three times daily for 90 days. The main goal was to see if the ulcer…

This study tested two types of special mattresses—the Fluid Immersion Simulation (FIS) system and the Air Fluidized Bed (AFB)—to see which helps heal surgically closed pressure ulcers (bedsores) better. Eighty adults with stage III or IV bedsores were randomly assigned to one mat…

This study tested whether adding placental tissue grafts to standard wound care helps close diabetic foot and venous leg ulcers faster. 292 adults with nonhealing ulcers received either standard care alone or standard care plus a graft. The main goal was to see if more ulcers clo…

This study tested whether adding a special collagen-based skin substitute to standard negative pressure wound therapy (NPWT) helps deep wounds heal faster than NPWT alone. It involved 104 adults with full-thickness wounds (at least 4 weeks old) that were not healing well. The mai…

This study tested a borate-based bioactive glass wound matrix (Mirragen) plus standard care against standard care alone for diabetic foot ulcers. 148 adults with diabetes and a foot ulcer were enrolled. The main goal was to see if the glass dressing helped more wounds close compl…

This phase 2 pilot study tested a topical ointment called MEBO on venous leg ulcers. Only 5 people took part, and they were randomly assigned to get either MEBO or standard compression bandages. The main goal was to see if the ulcer healed completely within 8 weeks. Because the s…

This study tested two doses of a daily pill called ozanimod in 198 Japanese adults with moderate to severe ulcerative colitis. The goal was to see if it could reduce symptoms and inflammation better than a placebo. The trial also checked long-term safety. Ozanimod works by calmin…

This study tested whether adding an injection of the antifungal drug voriconazole into the eye could improve treatment for fungal corneal ulcers. 70 people with moderate to severe infections received either standard antifungal drops alone or drops plus three injections over 10 da…

This small study tested ustekinumab, a drug that calms the immune system, in 16 adults with Behçet disease. The goal was to see if it could reduce mouth ulcers and eye inflammation. The trial is complete, but because it's early and small, we don't yet know if the drug will become…

This study tested a smartphone app called SeeWound 2 that uses artificial intelligence to measure the size, depth, and tissue makeup of hard-to-heal wounds. Instead of using a probe to touch the wound, the app takes a picture and calculates the measurements digitally. The study i…

This phase 3 trial tested whether ulinastatin, a drug that blocks certain enzymes, can reduce severe mouth sores caused by chemoradiotherapy in 179 patients with advanced nasopharyngeal cancer. Patients received either standard care or ulinastatin alongside their cancer treatment…

This study tested whether a special medical glue (isobutyl cyanoacrylate) can heal traumatic mouth ulcers in children better than standard treatments. Thirty children were split into three groups: one got the glue applied once, another got a chlorhexidine gel twice daily, and the…

This study looked at how well a special dressing called Aquacel WSF Ribbon works for healing foot ulcers and other wounds in everyday medical practice. Researchers reviewed the medical records of 214 people who used this dressing. The main goal was to see how long it took for wou…

This study aimed to create a better nursing plan for mouth sores caused by cancer treatments like chemo and radiation. Researchers worked with 54 cancer patients to test a new care routine based on the best available evidence. The goal was to reduce mouth soreness and improve dai…

This study looked at whether a special interactive dressing (UrgoStart Plus) used with compression bandages can help heal venous leg ulcers faster than standard dressings. Sixty adults with chronic leg ulcers were treated for up to 12 weeks. The goal was to see if the new dressin…

This study tested two treatments for painful mouth sores caused by radiation therapy: MEBO ointment and Tantum Verde mouthwash. 36 adults with moderate to severe sores were randomly assigned to one treatment for two weeks. Researchers measured soreness and healing at the start, a…

This study followed 190 adults who had or were about to have a stem cell transplant from a donor. Researchers tracked changes in the mouth, like dryness or sores, to learn more about chronic graft-versus-host disease (cGVHD). Participants provided saliva, mouth swabs, and had den…

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This completed study examined whether differences in the IL-7 receptor gene are linked to the risk of developing ulcerative colitis and how well patients respond to the drug vedolizumab. Researchers enrolled 898 people, including those with UC and healthy controls, and analyzed t…

This study looked at why people with sickle cell disease often get hard-to-heal leg ulcers. Researchers measured blood flow, nerve function, and blood markers in 70 patients with and without ulcers. The goal was to better understand what causes these wounds, not to test a new tre…