Toxic encephalopathy

This early-phase study tests a new type of CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to treatment. The cells are engineered to target and kill cancer cells, but also include a safety switch that can be activated to reduce severe side e…

This early-phase trial tests whether giving simvastatin (a cholesterol drug) and dexamethasone (a steroid) can safely prevent nerve-related side effects from axicabtagene ciloleucel (Axi-Cel) CAR-T therapy in adults with certain types of lymphoma. The study includes 37 participan…

This study tests whether the drug anakinra can prevent or reduce severe side effects like brain problems and cytokine release syndrome caused by CAR-T cell therapy. About 62 adults with certain B-cell blood cancers who are getting CAR-T treatment will receive anakinra. The goal i…

This phase 3 trial compares radiation therapy alone versus radiation plus the chemotherapy drug temozolomide for people with symptomatic or progressive low-grade gliomas. The study enrolled 540 adults and aims to see if adding chemo improves how long patients live without their t…

The TREX trial tests whether a low-dose combination of sevoflurane, remifentanil, and dexmedetomidine leads to better long-term brain development than standard-dose sevoflurane in children under 2 who need anesthesia for at least 2 hours. Researchers will randomly assign 450 chil…

This study looks at whether adding lorazepam to haloperidol can better reduce delirium (sudden confusion and agitation) in people with advanced cancer who are in a palliative care unit. About 93 participants will receive either haloperidol alone or with lorazepam, and their level…

This study tracks 193 people who swallowed the herbicide diquat to see how the amount of poison in their blood relates to damage in organs like the brain. Researchers will also look at how well blood-filtering treatments work. The goal is to better predict who is at highest risk …

This study looks at how a person's genes and medical history might help predict nerve damage caused by chemotherapy. Researchers will follow 300 people with certain cancers who are scheduled for specific chemo drugs. The goal is to find patterns that could help prevent or reduce …