Testicular cancer

This early-phase study tests the safety and best dose of a drug called veliparib when given with two chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors that have spread or can't be removed. It includes patients who also have liver or kidney probl…

This early-stage trial tests a new treatment for people with advanced solid tumors that have a specific marker called CLDN6. The treatment uses specially engineered immune cells (CAR-T cells) that target CLDN6, sometimes combined with a genetic booster (RNA-LPX) to enhance their …

This phase 2 trial tests whether reducing the intensity of chemotherapy and radiation can safely treat stage IIA/B seminoma, a type of testicular cancer. About 135 patients will receive either carboplatin alone or a combination of cisplatin and etoposide, along with lower-dose ra…

This phase 3 trial tests whether one course of BEP chemotherapy works better than one course of carboplatin to prevent seminoma testicular cancer from coming back after surgery. It includes 348 men with stage I seminoma who have risk factors like a large tumor or rete testis inva…

This phase 1 trial is testing a new imaging tracer called 68Ga-FAPI-46 to see where it collects in normal and cancerous tissues. About 30 people with various solid tumors or blood cancers will receive the tracer and then undergo a PET/CT scan. The goal is to understand how the tr…

This study tests whether low-dose CT scans can detect testicular cancer recurrence as well as standard CT scans, but with much less radiation. About 251 men with stage I testicular cancer will be monitored using low-dose CT. If it works, patients could avoid the long-term risks o…

This early study tests a new radioactive tracer called 68Ga-FAPI-46, which targets a protein (FAP) found around many tumors. About 26 people with various cancers will get a PET/CT scan using this tracer to see where it goes in the body. The goal is to learn if this tracer can hel…

This study tests a videoconference-based coaching program for testicular cancer survivors to help reduce fear of cancer recurrence and improve quality of life. About 70 survivors will be randomly assigned to either a coaching program based on Acceptance and Commitment Therapy (AC…

This study follows 250 young adult cancer survivors to see how their social relationships and physical activity change over time and how these factors affect their quality of life. Participants wear an activity tracker and complete surveys. The goal is to learn how to better supp…

This study uses a very powerful 7 Tesla MRI scanner to take detailed pictures of the brain in testicular cancer patients who have low testosterone (hypogonadism) and are on testosterone replacement therapy. The goal is to see if the MRI can detect changes in brain structure and f…

This study looks at whether a 12-week survivorship program for men with advanced prostate, kidney, bladder, testicular, or penile cancer can be successfully added to their regular follow-up care. Researchers will measure how feasible and acceptable the program is using questionna…

This study examines DNA from over 21,000 cancer patients in New York to find gene changes linked to several cancers, including breast, colon, and lung. Researchers will compare these genes to those from healthy people to spot differences. The goal is to generate ideas for future …

This study is testing whether a blood marker called miRNA 371 can predict if germ cell tumors (a type of cancer) will return after treatment. Researchers will collect blood samples from 956 newly diagnosed patients and track who has a relapse. The goal is to see if this marker ca…

This study follows nearly 1,000 testicular cancer survivors to understand why they have a higher risk of heart disease. Researchers are looking at how cancer treatments like chemotherapy may damage blood vessels or lead to risk factors like high blood pressure. The goal is to imp…