Substance withdrawal syndrome
MONDO:0005567A substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of a substance (including alcohol, prescribed medications and recreational drugs). Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions.
Also known as: drug withdrawal, drug withdrawal syndrome, substance withdrawal, substance withdrawal disorder, substance withdrawal syndrome, withdrawal syndrome, withdrawal disorder
158 clinical trials for this condition and its sub-types, 30 tagged with Substance withdrawal syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Substance withdrawal syndrome
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Neonatal abstinence syndrome 18 trials
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Alcohol withdrawal 11 trials · 13 incl. sub-types
1 sub-type
- Alcohol withdrawal delirium 2 trials
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Baclofen withdrawal syndrome 0 trials
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Methadone tested to shorten time on breathing machines in ICU
Symptom relief Stopped earlyThis study tested whether giving methadone to ICU patients on breathing machines could help them get off the ventilator faster. Patients who needed strong painkillers were given either methadone or a placebo. The trial was stopped early and only included 9 people, so no firm conc…
Phase 4 • Sponsor: Henry Ford Health System • Aim: Symptom relief
Last updated Jun 27, 2026 08:02 UTC
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Can a restless legs drug ease opioid withdrawal?
Symptom relief Stopped earlyThis study tested whether pramipexole (Mirapex), a drug for restless legs syndrome, could also reduce symptoms of opioid withdrawal in people with opioid use disorder. The trial planned to enroll 75 adults but was terminated early. Researchers measured changes in restless legs se…
Phase 2/3 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC