Skin basal cell carcinoma

This study tests whether combining an immunotherapy drug (cemiplimab), a topical cream (imiquimod), and laser therapy before surgery can cure high-risk basal cell skin cancer. About 18 adults with large or difficult-to-treat tumors will receive the combination or immunotherapy al…

This study tests a combination of two immunotherapy drugs (nivolumab and ipilimumab) along with two anti-rejection medications (sirolimus and prednisone) in kidney transplant recipients who have advanced skin cancer that cannot be surgically removed or has spread. The goal is to …

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This early-stage study tests a new drug called KUP-101A in 21 people with advanced skin cancers (like melanoma or Merkel cell carcinoma) that have not responded to other treatments. The main goals are to find the safest dose and check for side effects. Researchers will also measu…

This phase 2 trial tests three experimental drugs—L19IL2, L19TNF, or a combination—injected directly into skin tumors for people with advanced basal cell carcinoma who cannot have surgery or radiation. About 180 participants will receive weekly injections for four weeks and be fo…

This phase 2 trial tests a new drug combination, L19IL2/L19TNF, injected directly into skin tumors. It is for people with advanced basal cell carcinoma that has worsened despite or cannot tolerate standard treatments. The study will enroll 92 participants and track how many respo…

This study tests a new device that delivers a special type of radiation directly into skin tumors. The goal is to see if it can shrink or control the cancer. The study is for adults with certain types of skin cancer, including squamous cell carcinoma and basal cell carcinoma. Par…

This study compares four different dosing schedules of the drug vismodegib in people with advanced basal cell carcinoma. The goal is to see if personalized, intermittent dosing works as well as or better than standard continuous dosing while being easier to tolerate. About 34 adu…

This phase 2 trial is testing the drug cemiplimab as a first-line treatment for people with advanced basal cell carcinoma who have not received prior therapy. The study will enroll 34 participants and measure how many patients see their tumors shrink or disappear after six months…

This study is for people with advanced basal cell skin cancer that has completely disappeared after taking targeted pills (vismodegib or sonidegib). The problem is that the cancer often returns when the pills are stopped. Researchers want to see if giving a short course of radiat…

This study tests whether a special laser followed by tirbanibulin ointment can effectively treat common skin cancers like basal and squamous cell carcinoma. About 100 adults with biopsy-confirmed skin cancers will receive the laser treatment and, if needed, apply the ointment for…

This study tests whether two-photon fluorescence microscopy can accurately diagnose skin biopsies, including basal cell carcinoma, squamous cell carcinoma, and melanocytic lesions. Researchers will compare images from this technique with standard pathology results to measure its …

This study tests whether a machine learning model can accurately diagnose two common types of skin cancer—basal cell carcinoma and squamous cell carcinoma—by analyzing images from a special microscope (two-photon microscopy) that scans skin biopsy samples. The goal is to see if t…

This study tests three non-invasive imaging devices on adults with basal cell carcinoma, the most common skin cancer. Researchers measure how long each scan takes, how comfortable it feels, and how well the tools work on different body areas. Participants attend one 40-minute vis…

This study tracks 70 skin cancer patients to see how long it takes to get insurance approval for off-label neoadjuvant therapy (treatment before surgery). Researchers will measure approval times, out-of-pocket costs, and whether delays lead to worse surgical outcomes. The goal is…

This study aims to find out how often Muir-Torre syndrome (MTS) occurs in people who already have Lynch syndrome, a genetic condition that raises cancer risk. Researchers will examine skin lesions and tumors from 150 participants to see if they are linked to MTS. The goal is to b…

This study is building a large French database of patients with three rare skin cancers: Merkel cell carcinoma, advanced basal cell carcinoma, and cutaneous adnexal carcinomas. Researchers will track up to 9,000 participants to learn how these cancers behave, what factors affect …