Skin appendage disorder

Researchers are testing an experimental topical gel called PP405 in men with androgenetic alopecia, the most common form of male pattern hair loss. The trial enrolls about 600 men aged 18 to 55 with moderate hair loss at the top of the scalp. Participants apply either the PP405 g…

Researchers are examining how well ritlecitinib works for people with alopecia areata when prescribed in everyday medical practice rather than in a controlled trial. The study draws on US electronic health records and insurance claims for about 7,500 patients aged 12 and older wh…

This trial tests two food supplements for hair health in men aged 35 to 65 with mild to moderate male pattern baldness. Participants take one capsule daily for 84 days, and researchers compare the supplements against a placebo. The study measures changes in hair density, hair los…

This Phase 3 trial tests a new topical drug called APSMNF for male pattern baldness. About 336 men aged 18 to 60 will apply it twice daily for 24 weeks. Researchers will measure changes in hair density using a special camera and track any side effects.

This Phase 2 trial tests a cream called delgocitinib in 30 adults with frontal fibrosing alopecia, a condition that causes hair loss at the front of the scalp. Everyone in the study will use the cream for 24 weeks. Researchers will measure changes in hairline and hair counts to s…

This study tests whether omega-3 supplements or a special anti-demodex eyelid cleanser can help treat and prevent chalazia (styes) in children aged 4 to 17. All 168 participants will use warm compresses, and they will be split into three groups: one adds omega-3 fish oil and stan…

This pilot study will test whether a daily gummy supplement called Xtressé can safely improve hair growth in 40 men with male pattern baldness. Participants take two gummies each day for six months, and researchers measure changes in hair density and thickness using special camer…

This early-stage trial is testing an experimental oral medication called VC005 in adolescents aged 12 to 18 with severe alopecia areata, a condition that causes patchy or complete hair loss. The study aims to understand how the drug is processed by the body, whether it is safe, a…

This pilot trial tests whether tirzepatide, a weekly injection used for diabetes and weight loss, can treat active central centrifugal cicatricial alopecia (CCCA), a permanent scarring hair loss condition. Twenty adults with active CCCA will inject tirzepatide for 12 months and u…

This study tests whether an injection called XVIE, made from processed human amniotic fluid, is safe and might help regrow hair in adults with common pattern baldness. Thirty participants will receive either XVIE or a placebo injected into the scalp, with two treatments 90 days a…

This trial investigates whether combining microneedling with a standard 5% minoxidil solution can improve hair regrowth in men with androgenetic alopecia (male pattern baldness). It will enroll 190 men aged 18-55 with specific hair loss grades, who will receive different micronee…

This trial is testing whether giving two drugs—sintilimab and disitamab vedotin—before surgery can shrink tumors in people with a rare type of eyelid cancer called sebaceous gland carcinoma. Participants receive two cycles of the combination, then undergo surgery to remove the tu…

This trial compares three types of platelet-rich plasma (PRP) injections for androgenetic alopecia, the most common form of hair loss. Participants receive either standard PRP, PRP enhanced with red light, or PRP enhanced with blue light, and are blinded to which type they get. T…

This trial investigates whether fecal microbiota transplantation (FMT) can treat alopecia areata, an autoimmune condition causing patchy hair loss. Researchers will give adults with alopecia areata either FMT or a placebo for three days and track hair regrowth, immune changes, an…

This trial tests whether a custom cream containing metformin (a diabetes drug), simvastatin (a cholesterol drug), and betamethasone (a steroid) can regrow hair in people with patchy alopecia areata, an autoimmune condition causing hair loss. Participants apply the cream twice dai…

This study tests whether a daily oral minoxidil pill (N1087) can help regrow hair in men with male pattern baldness. About 372 men aged 18 to 60 with moderate hair loss will take either the drug or a placebo for 24 weeks, with the dose slowly increased. The main goal is to see if…

This study tests whether a treatment called DA-001 can safely reduce hair shedding and promote regrowth in people with certain types of hair loss, including telogen effluvium and female or male pattern baldness. About 1,120 adults will apply the treatment as directed and be monit…

This study tests whether a single injection of nanofat (processed fat from your own body) can treat pattern hair loss better than standard options. Sixty adults with androgenetic alopecia will receive either one nanofat injection, three monthly PRP injections, or daily topical mi…

This study tests a daily pill called upadacitinib for people with severe forms of lichen planus, a skin disease causing painful mouth sores or hair loss. About 56 adults will receive either the drug or a placebo for 16 weeks to see if it reduces symptoms. The goal is to control t…

This early-stage study tests two forms of a hair loss drug (AD-303A topical and AD-3031 oral) in 30 men aged 19-55 with male pattern baldness. The goal is to see how the drug moves through the body, how well it works, and if it is safe. The study will help decide the right dose f…

This study tests whether a gel containing methotrexate, an immune-suppressing drug, can regrow hair in people with localized alopecia areata better than minoxidil spray. About 268 adults with less than 25% scalp hair loss will apply one of the two treatments twice daily for 24 we…

This study tests whether a vitamin D-based cream (calcipotriol) works as well as steroid injections for regrowing hair in people with patchy alopecia areata. Sixty adults with less than half their scalp affected will use one of the two treatments for 12 weeks. The goal is to see …

This study tests if intense pulsed light (IPL) is a safe and effective way to treat chalazion, a common eyelid lump. About 40 adults with an inflamed chalazion will receive IPL or a control treatment. The main goal is to see if the lump shrinks by at least 80% four weeks after th…

This study compares two oral medications—tofacitinib and methotrexate—for treating severe alopecia areata, an autoimmune condition causing hair loss. 78 adults aged 18-60 with severe scalp or total body hair loss will take one of the drugs for 12 weeks. The main goal is to see wh…

This Phase 3 trial tests whether an oral solution called N1087 can help women with female pattern hair loss regrow hair. About 372 women aged 18 to 60 will receive either N1087 or a placebo daily for 24 weeks. The study measures changes in hair density and thickness using scalp p…

This phase 3 trial is testing whether an oral (pill) form of arsenic trioxide works as well as the standard IV form for consolidation therapy in people with a low-risk type of acute promyelocytic leukemia (APL). About 120 adults and teens who have already completed initial treatm…

This study tests whether adding platelet-rich plasma (PRP) or nanofat injections to standard hair transplants helps more hair grafts survive and grow thicker. Thirty men with stable male pattern baldness will receive both treatments on different scalp areas, and doctors will meas…

This early study will test a new device called the LuSeed Aneurysm Embolization System in 10 people with unruptured brain aneurysms. The device is designed to block blood flow to the aneurysm, reducing the risk of rupture. The main goals are to see if the device is safe and can b…

This study compares two forms of minoxidil—a topical spray and an oral pill—for treating androgenetic alopecia (common hair loss) in 200 men and women aged 18 to 50. Over 6 months, researchers will measure hair regrowth, shedding, and side effects. Participants will use either th…

This study tests biologic drugs for folliculitis decalvans, a rare scalp disease that causes painful pustules and permanent hair loss. Current antibiotics only work about half the time and the condition often returns. The trial will enroll 120 adults who have already tried at lea…

This study tests whether adding a stem-cell-derived exosome solution to fractional laser therapy helps regrow hair better than laser alone. Thirty men with male pattern baldness will receive three laser sessions and be followed for six months. Researchers will measure changes in …

This study compares two medicines, hydroxychloroquine and methotrexate, to see which works better for frontal fibrosing alopecia, a type of scarring hair loss that mainly affects women. About 50 adults who choose to start one of these treatments will be followed for up to 48 week…

This study tests whether platelet-rich plasma (PRP) injections can help treat central centrifugal cicatricial alopecia (CCCA), a scarring hair loss that mostly affects women of African descent. PRP is made from a patient's own blood and is thought to reduce inflammation and promo…

This study aims to train and test artificial intelligence (AI) models to diagnose male and female pattern hair loss (androgenetic alopecia) and assess its severity. Researchers will use images from a handheld dermoscope along with age and sex data from 400 participants. The goal …

Researchers are testing a modified surgical technique for squamous cell carcinoma in situ on the scalp, an early form of skin cancer. Standard surgery can remove deep tissue that holds hair follicles, causing permanent bald spots. This pilot study uses partial thickness excision,…

This study tests whether adding low-level red-light therapy to the standard hair-loss treatment minoxidil helps breast cancer patients regrow hair lost during chemotherapy. About 50 adults with stage I-IV breast cancer who lost at least half their scalp hair after chemo will be e…

This trial investigates whether a dietary supplement can reduce hair loss in women who experience telogen effluvium—a type of temporary shedding—while taking GLP-1 medications like semaglutide or tirzepatide. Over 120 days, participants will take the supplement daily, and researc…

This study tests if a special cooling cap can reduce hair loss in people with advanced solid tumors who are receiving a type of chemotherapy called antibody-drug conjugates (ADCs). About 102 women will be split into two groups: one gets the cooling cap during treatment, the other…

This early-stage study tests whether platelet-rich plasma (PRP) therapy, made from a participant's own blood, can help women with androgenic alopecia (female pattern hair loss). Sixteen women will receive PRP injections, and researchers will measure changes in hair loss severity …

Researchers at Al-Azhar University are studying whether type 2 diabetes is linked to changes in women's hair and scalp. The study compares 130 women aged 20 to 60, half with diabetes for at least a year and half healthy controls matched by age. Participants undergo clinical hair …

This observational study aims to collect and analyze data from up to two million patients with dermatologic conditions like vitiligo, atopic dermatitis, alopecia areata, and hidradenitis suppurativa, as well as their healthcare providers. By reviewing treatment patterns, outcomes…

This study investigates whether the bacteria living in the gut and on the scalp differ between men with androgenetic alopecia (common hair loss) and those without. Researchers will also look at how these bacterial communities change after treatment with oral minoxidil, a standard…

This study measures how often depression occurs in adults with alopecia areata, a condition that causes patchy hair loss. Researchers will use a questionnaire to assess depressive symptoms in 100 patients at a dermatology clinic. No treatments or interventions are involved — the …

This early-stage study tests a drug called DA-020 in 60 healthy women aged 18-55. The goal is to measure how much of the drug enters the blood after one application to the scalp and to check for side effects like blood pressure changes. This research helps understand the drug's s…

This study will collect existing medical records from about 20,000 people aged 12 and older in Italy who have one of five inflammatory skin conditions: psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to describe who gets thes…