Severe pre-eclampsia
MONDO:0001641Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.
Also known as: Preeclampsia with severe features, severe preeclampsia
59 clinical trials for this condition and its sub-types, 27 tagged with Severe pre-eclampsia itself.
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Sub-types of Severe pre-eclampsia
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HELLP syndrome 13 trials
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Can a blood filter help mothers with severe preeclampsia carry longer?
Disease control Not yet recruitingThis trial tests whether a device called the KNP-1000 apheresis system is safe for pregnant women with severe preeclampsia and their babies. The device filters the mother's blood to remove a protein linked to the condition. Researchers will enroll about 13 women between 23 and 32…
Sponsor: Kaneka Medical America LLC • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Could cutting salt after childbirth tame dangerous blood pressure?
Disease control Not yet recruitingThis trial tests whether a low-sodium diet can improve blood pressure control in people who had a hypertensive disorder of pregnancy. Participants receive either a provided diet with less than 2000 mg of sodium per day or a standard diet with no salt restrictions for the first we…
Sponsor: Women and Infants Hospital of Rhode Island • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New blood test could prevent dangerous delays in preeclampsia deliveries
Disease control Not yet recruitingThis study tests whether a blood test measuring the sFlt-1/PlGF ratio can help doctors decide the best time to deliver babies in women with severe early-onset preeclampsia. The trial will include 386 pregnant women between 30 and 34 weeks of gestation. Half will have delivery tim…
Sponsor: Hospital Clinic of Barcelona • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Could a simple mist prevent dangerous blood pressure spikes during C-Sections?
Disease control Not yet recruitingThis study tests whether breathing in a sedative called dexmedetomidine before anesthesia can prevent sudden blood pressure rises during emergency C-sections in women with severe preeclampsia. One hundred participants will be randomly assigned to receive either the drug or a plac…
Sponsor: Assiut University • Aim: Disease control
Last updated Jun 26, 2026 16:50 UTC
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Finger clip could guide fluid treatment in dangerous pregnancy condition
Diagnosis Not yet recruitingThis study looks at whether a noninvasive finger monitor can predict how pregnant women, including those with severe preeclampsia, respond to fluids. Researchers will compare the finger device to standard heart ultrasound in 88 women. The goal is to find a simpler way to guide fl…
Sponsor: Stanford University • Aim: Diagnosis
Last updated Jun 27, 2026 09:07 UTC
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Could a safer drug replace magnesium for seizure prevention in pregnancy?
Prevention Not yet recruitingThis study tests whether levetiracetam, a seizure medication, works as well as magnesium sulfate to prevent seizures in pregnant people with severe preeclampsia. About 1,240 participants at 32 weeks or more will be randomly assigned to one of the two drugs. The goal is to see if …
Phase 3 • Sponsor: Nebraska Methodist Health System • Aim: Prevention
Last updated Jun 27, 2026 07:55 UTC
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Could a simple water pill get moms home faster after severe preeclampsia?
Symptom relief Not yet recruitingThis study tests whether a common water pill (furosemide) can help women with severe preeclampsia recover faster after childbirth and leave the hospital sooner. About 186 women will receive either furosemide or a placebo starting 12 hours after delivery. The goal is to see if the…
Phase 2 • Sponsor: Universidad Nacional Autonoma de Honduras • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Shorter magnesium dosing studied for postpartum preeclampsia recovery
Knowledge-focused Not yet recruitingThis study looks at how blood test results change after delivery in people with severe preeclampsia. Participants are randomly assigned to receive magnesium for either 12 or 24 hours after birth. The goal is to see if a shorter treatment is safe and effective, and to understand h…
Phase 4 • Sponsor: Alexander Harrison • Aim: Knowledge-focused
Last updated Sep 11, 2026 00:00 UTC
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Genetic clues to severe preeclampsia could transform early detection
Knowledge-focused Not yet recruitingThis study investigates genetic and molecular markers in pregnant women with severe preeclampsia, a dangerous condition involving high blood pressure and organ damage. Researchers will analyze blood, urine, and placental samples from 100 women to identify changes in genes and cel…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jul 16, 2026 00:00 UTC
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Why does labetalol fail in severe preeclampsia? new study aims to find out
Knowledge-focused Not yet recruitingSevere preeclampsia is a dangerous pregnancy complication that can cause high blood pressure, harming both mother and baby. This observational study will follow 350 women to identify factors that make blood pressure control with the drug labetalol fail. By understanding these fac…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC