Semantic dementia

This early-phase trial tests a gene therapy called AVB-101 for people with frontotemporal dementia caused by GRN gene mutations. The therapy delivers a working copy of the GRN gene directly into the brain during a one-time procedure. The study will enroll 18 adults aged 30-75 to …

This study aims to find the best cutoff values for key Alzheimer's-related proteins in spinal fluid and blood to improve diagnostic accuracy. Researchers will compare results from Alzheimer's patients, those with mild memory problems, people with other dementias, and healthy olde…

This study is testing a new blood test called the AD-seeds-detector that looks for specific protein clumps linked to Alzheimer's disease. Researchers will compare the test results from 1,500 people aged 55-75, including those with Alzheimer's, other dementias, and healthy individ…

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exerc…

This study tests a speech therapy program for bilingual Spanish-English or Spanish-Catalan speakers with primary progressive aphasia, a condition that slowly damages language abilities. Sixty participants will receive personalized script training via video sessions, while 30 othe…

This study tests a non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can improve cognitive function in people with mild cognitive impairment or early Alzheimer's disease. Sixty participants will receive either real TIS or a sham …

This study tests a personalized, virtual speech therapy program for people with primary progressive aphasia (a type of dementia that affects language) and their communication partners. The goal is to see if the program improves communication and quality of life. About 30 particip…

This study is testing whether a safe, non-invasive brain stimulation technique called rTMS can help people with frontotemporal dementia (FTLD) or those at risk. 120 participants will receive either real or placebo stimulation for 2 weeks, then all will get real stimulation. Resea…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This long-term study follows people with or at genetic risk for frontotemporal lobar degeneration (FTLD), a group of brain disorders that cause changes in behavior, language, and movement. Researchers will use brain scans, memory tests, and blood samples to measure how the diseas…

This study looks at how social and emotional thinking skills relate to everyday behavior in people with Alzheimer's disease and similar conditions. Researchers will give 120 participants tests of social cognition and ask their study partners to complete behavior checklists. They …

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study aims to find new biological markers for neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will analyze genetic, protein, and metabolic data from 1,200 patients to improve diagnosis, predict disease course, and monitor treatment response. Th…

This study uses a special PET scan to measure tau protein buildup in the brains of people with frontotemporal lobar degeneration (FTLD), atypical Alzheimer's disease, and healthy volunteers. Researchers want to see if this scan can help tell these conditions apart. About 72 adult…