Secondary hemophagocytic lymphohistiocytosis
MONDO:0015542Hemophagocytic lymphohistiocytosis due to infections, autoimmune disorders, or underlying malignancies. Signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia.
Also known as: acquired hemophagocytic lymphohistiocytosis, acquired hemophagocytic syndrome, reactive hemophagocytic syndrome
24 clinical trials for this condition and its sub-types, 15 tagged with Secondary hemophagocytic lymphohistiocytosis itself.
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Sub-types of Secondary hemophagocytic lymphohistiocytosis
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Macrophage activation syndrome 13 trials
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Can a cancer drug tame a dangerous immune storm?
Disease control Recruiting nowThis early study tests the drug ruxolitinib for a rare but serious condition called IEC-HS, which can happen after CAR-T therapy for cancer. The condition causes a dangerous overreaction of the immune system. The trial will include 16 adults and aims to see if the drug is safe an…
Phase 1 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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New drug targets Life-Threatening immune storm in rheumatic patients
Disease control Recruiting nowThis phase 3 trial tests a drug called plonmarlimab in 30 adults with a severe immune overreaction (macrophage activation syndrome) linked to rheumatic diseases that hasn't responded to prior treatment. Participants receive weekly IV infusions for 8 weeks. The main goal is to see…
Phase 3 • Sponsor: TJ Biopharma Co., Ltd. • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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New drug targets deadly immune overreaction in rare disease
Disease control Recruiting nowThis study tests a new drug, ELA026, for people with secondary hemophagocytic lymphohistiocytosis (sHLH), a rare and life-threatening condition where the immune system becomes dangerously overactive. The drug aims to calm this overreaction by removing certain immune cells. The tr…
Phase 2/3 • Sponsor: Electra Therapeutics Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New drug could tame deadly immune storm in kids before transplant
Disease control Recruiting nowThis study tests a drug called ruxolitinib as the first treatment for children with a rare, life-threatening immune condition called primary HLH. The goal is to calm the overactive immune system and help more children survive long enough to receive a stem cell transplant. The tri…
Phase 2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New hope for kids: drug may shield against dangerous viruses after transplant
Disease control Recruiting nowThis study tests whether the drug letermovir can prevent serious viral infections in children with EBV-related blood disorders who receive a stem cell transplant. About 80 children will be enrolled, and researchers will monitor for infections and other transplant complications. T…
Sponsor: Beijing Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Cord blood transplant offers new hope for rare EBV diseases
Disease control Recruiting nowThis study tests whether a transplant of donated umbilical cord blood can help people aged 14 to 80 with serious diseases caused by the Epstein-Barr virus (EBV), such as certain lymphomas or chronic active EBV infection. The goal is to control the disease and improve survival, bu…
Phase 2 • Sponsor: Fudan University • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Researchers launch study to unravel mysteries of rare immune disorder sHLH
Knowledge-focused Recruiting nowThis study aims to understand why some adults develop secondary hemophagocytic lymphohistiocytosis (sHLH), a serious immune condition causing fevers and organ damage. Researchers will follow 300 participants for up to 3 years, collecting blood samples and medical data to identify…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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New study sheds light on mysterious immune disease in adults
Knowledge-focused Recruiting nowThis study is following 81 adults with a rare condition called hemophagocytic lymphohistiocytosis (HLH), where the immune system becomes dangerously overactive. Researchers aim to better understand the disease's features and how patients respond to treatments like steroids and ch…
Sponsor: Samsung Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC