Sarcoma
MONDO:0005089A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma.
Also known as: mesenchymal tumor, malignant, sarcoma, sarcoma of soft tissue and bone, sarcoma of the soft tissue and bone, sarcoma, malignant, tumor of soft tissue and skeleton, tumour of soft tissue and skeleton
3687 clinical trials for this condition and its sub-types, 493 tagged with Sarcoma itself.
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Sub-types of Sarcoma
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Soft tissue sarcoma 297 trials · 646 incl. sub-types
46 sub-types
- Rhabdomyosarcoma 100 trials · 114 incl. sub-types Sub-types →
- Liposarcoma 58 trials · 83 incl. sub-types Sub-types →
- Angiosarcoma 37 trials · 82 incl. sub-types Sub-types →
- Rhabdoid tumor 63 trials · 75 incl. sub-types Sub-types →
- Central nervous system sarcoma 2 trials · 74 incl. sub-types Sub-types →
- Leiomyosarcoma 62 trials · 72 incl. sub-types Sub-types →
- Synovial sarcoma 53 trials Sub-types →
- Undifferentiated pleomorphic sarcoma 48 trials Sub-types →
- Desmoplastic small round cell tumor 26 trials
- Fibrosarcoma 9 trials · 21 incl. sub-types Sub-types →
- Myxofibrosarcoma 21 trials
- Alveolar soft part sarcoma 20 trials Sub-types →
- Epithelioid sarcoma 20 trials Sub-types →
- Retroperitoneal sarcoma 17 trials Sub-types →
- Clear cell sarcoma 14 trials · 16 incl. sub-types Sub-types →
- Liver sarcoma 1 trial · 10 incl. sub-types Sub-types →
- Skin sarcoma 1 trial · 9 incl. sub-types Sub-types →
- SMARCA4-deficient sarcoma of thorax 8 trials
- Kidney sarcoma 0 trials · 8 incl. sub-types Sub-types →
- Extraskeletal myxoid chondrosarcoma 7 trials Sub-types →
- Intimal sarcoma 4 trials
- Breast sarcoma 2 trials · 3 incl. sub-types Sub-types →
- Extraskeletal Ewing sarcoma 3 trials
- Undifferentiated round cell sarcoma 3 trials
- Extraosseous osteosarcoma 2 trials Sub-types →
- Ovarian sarcoma 0 trials · 2 incl. sub-types Sub-types →
- Heart sarcoma 1 trial Sub-types →
- Small intestinal sarcoma 0 trials · 1 incl. sub-types Sub-types →
- Testis sarcoma 0 trials · 1 incl. sub-types Sub-types →
- Anus sarcoma 0 trials Sub-types →
- Bladder sarcoma 0 trials
- Esophagus sarcoma 0 trials Sub-types →
- Gallbladder sarcoma 0 trials Sub-types →
- Laryngeal sarcoma 0 trials Sub-types →
- Lung sarcoma 0 trials Sub-types →
- Mediastinum sarcoma 0 trials Sub-types →
- Myxosarcoma 0 trials
- Pancreas sarcoma 0 trials
- Paranasal sinus sarcoma 0 trials
- Penile sarcoma 0 trials
- Prostate sarcoma 0 trials Sub-types →
- Stromal sarcoma 0 trials Sub-types →
- Thyroid sarcoma 0 trials Sub-types →
- Trachea sarcoma 0 trials
- Vagina sarcoma 0 trials Sub-types →
- Vulva sarcoma 0 trials Sub-types →
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Osteosarcoma 169 trials · 173 incl. sub-types
6 sub-types
- Localized osteosarcoma 13 trials
- Bone osteosarcoma 8 trials Sub-types →
- Pediatric osteosarcoma 8 trials Sub-types →
- Extraosseous osteosarcoma 2 trials Sub-types →
- Low grade central osteosarcoma 0 trials
- Multifocal osteogenic sarcoma 0 trials Sub-types →
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Ewing sarcoma 125 trials · 126 incl. sub-types
2 sub-types
- Ewing sarcoma of bone 5 trials
- Extraskeletal Ewing sarcoma 3 trials
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Bone sarcoma 41 trials · 108 incl. sub-types
13 sub-types
- Undifferentiated pleomorphic sarcoma 48 trials Sub-types →
- Dedifferentiated chondrosarcoma 9 trials
- Bone giant cell tumor 7 trials · 8 incl. sub-types Sub-types →
- Bone osteosarcoma 8 trials Sub-types →
- Ewing sarcoma of bone 5 trials
- Undifferentiated high grade pleomorphic sarcoma of bone 4 trials
- Clear cell chondrosarcoma 3 trials
- Malignancy in giant cell tumor of bone 1 trial
- Bone angiosarcoma 0 trials
- Bone fibrosarcoma 0 trials
- Bone leiomyosarcoma 0 trials
- Liposarcoma of bone 0 trials
- Periosteal chondrosarcoma 0 trials
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Dendritic cell sarcoma 0 trials · 53 incl. sub-types
3 sub-types
- Interdigitating dendritic cell sarcoma 53 trials
- Follicular dendritic cell sarcoma 2 trials
- Langerhans cell sarcoma 0 trials
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Chondrosarcoma 39 trials · 44 incl. sub-types
4 sub-types
- Bone chondrosarcoma 1 trial · 10 incl. sub-types Sub-types →
- Mesenchymal chondrosarcoma 4 trials Sub-types →
- Myxoid chondrosarcoma 2 trials Sub-types →
- Localized chondrosarcoma 0 trials
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Small cell sarcoma 0 trials · 37 incl. sub-types
6 sub-types
- Desmoplastic small round cell tumor 26 trials
- EWSR1-negative small round cell tumor 0 trials · 5 incl. sub-types Sub-types →
- Mesenchymal chondrosarcoma 4 trials Sub-types →
- Round cell sarcoma with EWSR1-non-ETS fusion 2 trials Sub-types →
- Sarcoma with BCOR genetic alterations 1 trial · 2 incl. sub-types Sub-types →
- Small cell osteogenic sarcoma 0 trials
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Myeloid sarcoma 28 trials
1 sub-type
- Granulocytic sarcoma 0 trials
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Uterine corpus sarcoma 12 trials · 19 incl. sub-types
3 sub-types
- Leiomyosarcoma of the corpus uteri 9 trials Sub-types →
- Uterine corpus endometrial stromal sarcoma 0 trials
- Uterine corpus rhabdomyosarcoma 0 trials
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Spindle cell sarcoma 6 trials · 13 incl. sub-types
4 sub-types
- Intimal sarcoma 4 trials
- Spindle cell rhabdomyosarcoma 3 trials Sub-types →
- Spindle cell liposarcoma 0 trials
- Spindle cell synovial sarcoma 0 trials
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Endometrioid stromal sarcoma 2 trials
3 sub-types
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Ectomesenchymoma 1 trial
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Giant cell tumor of soft tissue 1 trial
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Sarcomatosis 1 trial
1 sub-type
- Sarcomatosis of the meninges 0 trials
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Colon sarcoma 0 trials
2 sub-types
- Colon Kaposi sarcoma 0 trials
- Colon leiomyosarcoma 0 trials
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Lymphangiosarcoma 0 trials
1 sub-type
- Skin lymphangiosarcoma 0 trials
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Mast cell sarcoma 0 trials
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Orbit sarcoma 0 trials
1 sub-type
- Orbit rhabdomyosarcoma 0 trials Sub-types →
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Rectum sarcoma 0 trials
4 sub-types
- Anus sarcoma 0 trials Sub-types →
- Rectum Kaposi sarcoma 0 trials
- Rectum leiomyosarcoma 0 trials Sub-types →
- Rectum rhabdomyosarcoma 0 trials Sub-types →
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Reticulum cell sarcoma 0 trials
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Sarcoma G1 0 trials
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Sarcoma of cervix uteri 0 trials
5 sub-types
Most studied deeper sub-types
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New combo therapy shows promise in early sarcoma trial
Disease control Stopped earlyThis study tests a new drug (ADI-PEG 20) combined with chemotherapy and radiation before surgery for soft tissue sarcoma. The goal is to find the safest dose and see how well it shrinks tumors. Only 6 patients with intermediate or high-grade sarcoma of the trunk or limbs are taki…
Phase 1 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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Early trial combines two chemo drugs with radiation for aggressive sarcomas
Disease control Stopped earlyThis Phase 1 trial tested a combination of two chemotherapy drugs (gemcitabine and docetaxel) given alongside radiation therapy for adults with large (over 5 cm), high-grade soft tissue sarcoma of the arms or legs. The goal was to find the safest dose and see how well the body to…
Phase 1 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Experimental drug combo for rare sarcoma shows promise, but trial halted early
Disease control Stopped earlyThis phase 3 trial tested whether adding ADI-PEG 20 to standard chemotherapy (gemcitabine and docetaxel) could help people with advanced leiomyosarcoma, a rare soft tissue cancer. The study planned to enroll 218 participants whose cancer had progressed after prior treatment. Unfo…
Phase 3 • Sponsor: Polaris Group • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Experimental cancer therapy targets tough tumors with radioactive precision
Disease control Stopped earlyThis early-stage trial tested a two-step radioimmunotherapy combining GD2-SADA and 177Lu-DOTA in patients with recurrent or metastatic solid tumors, including small cell lung cancer, high-risk neuroblastoma, sarcoma, and melanoma. The goal was to assess safety and find the right …
Phase 1 • Sponsor: Y-mAbs Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Experimental cell therapy targets Hard-to-Treat sarcoma
Disease control Stopped earlyThis phase 2 trial tested a new cell therapy called TAEST16001 in 8 adults with advanced soft tissue sarcoma that had stopped responding to standard treatments. The therapy uses specially engineered immune cells to attack cancer cells that carry a specific marker (NY-ESO-1) in pa…
Phase 2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 13:08 UTC
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Focused ultrasound trial for rare sarcoma halted early
Disease control Stopped earlyThis study tested whether focused ultrasound could partially destroy a rare soft-tissue cancer called undifferentiated pleomorphic sarcoma and boost the body's immune response. Only 5 people were enrolled before the trial was terminated. The main goal was to check safety and see …
Sponsor: Matthew Bucknor • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New cocktail of cancer drugs tested in desperate cases
Disease control Stopped earlyThis early-phase trial tested combinations of the drugs bevacizumab and temsirolimus, sometimes with valproic acid or cetuximab, in 154 people with advanced cancers or certain non-cancerous but progressive diseases. The main goal was to find safe doses and look for any signs that…
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Tailored cancer therapy put to the test
Disease control Stopped earlyThis study tested a precision medicine approach for people with advanced cancers like breast, ovarian, pancreatic, prostate, or sarcoma. Researchers used genetic and protein tests to track how the cancer changes and then a team of experts recommended personalized drugs. The goal …
Phase 2 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Pazopanib dose hunt in frail seniors halted early
Disease control Stopped earlyThis phase 1 study tested the cancer drug pazopanib in 18 frail elderly patients (aged 75+) with metastatic cancers like kidney, lung, or breast cancer. The goal was to find the highest safe dose by starting at 400 mg daily and increasing if tolerated. The study was terminated ea…
Phase 1 • Sponsor: Institut Claudius Regaud • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Experimental cancer drug TNG908 tested in patients with rare gene deletion
Disease control Stopped earlyThis study tested an experimental oral drug called TNG908 in people with advanced solid tumors that have lost a gene called MTAP. The goal was to see if the drug is safe and can shrink tumors. The study was planned for up to 192 participants but was terminated early, so results a…
Phase 1/2 • Sponsor: Tango Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Experimental drug tested for rare cancer, trial stopped early
Disease control Stopped earlyThis study tested a drug called XmAb23104 in people with advanced sarcoma, a rare cancer. The goal was to see if the drug could shrink tumors and if it was safe. Only 6 people took part before the study was ended early.
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Immune cell therapy tested for tough childhood cancers
Disease control Stopped earlyThis early-phase study tested a treatment using donated natural killer (NK) cells from cord blood, combined with chemotherapy, for children and young adults with solid tumors that returned or didn't respond to standard care. The goal was to find the safest dose and check for side…
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Experimental drug combo targets sarcoma before surgery
Disease control Stopped earlyThis early-stage trial tested a drug called AZD1390, which blocks DNA repair, given with or without an immunotherapy (durvalumab) plus standard radiation before surgery for soft tissue sarcoma. The goal was to see if the combination is safe and tolerable, especially regarding wou…
Phase 1 • Sponsor: The Netherlands Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New cancer drug OC-001 tested in advanced tumors – trial ends early
Disease control Stopped earlyThis early-phase trial tested an experimental drug called OC-001, given alone or with the immunotherapy avelumab, in 73 people with various advanced or metastatic cancers (like lung, breast, and bladder cancer). The main goals were to check safety and how the drug moves through t…
Phase 1/2 • Sponsor: Ocellaris Pharma, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Cancer-Fighting virus injected directly into tumors shows promise in early trial
Disease control Stopped earlyThis early-phase trial tested a new treatment called BT-001, a virus designed to infect and kill cancer cells, given alone or with the immunotherapy drug pembrolizumab. The study involved 31 people with advanced solid tumors like melanoma, lung cancer, or sarcoma that had spread.…
Phase 1/2 • Sponsor: Transgene • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Experimental cancer drug study halted early
Disease control Stopped earlyThis study tested an experimental drug called SQ3370 in 53 people with advanced solid tumors that had spread or could not be removed by surgery. The goal was to check the drug's safety and find the best dose, as well as see if it could shrink tumors. The study was terminated earl…
Phase 1/2 • Sponsor: Shasqi, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Experimental cancer drug trial halted early
Disease control Stopped earlyThis early-stage study tested a new drug called HFB301001 in 31 adults with advanced solid tumors (like sarcoma, kidney cancer, or melanoma) that had not responded to prior treatments. The main goal was to check the drug's safety and find the best dose. The study was terminated, …
Phase 1 • Sponsor: HiFiBiO Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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New drug tested for tough cancers
Disease control Stopped earlyThis early-stage study tested a new drug called ACTM-838 in 10 people with advanced solid tumors that no longer responded to standard treatments. The main goals were to check safety and find the right dose. The study was stopped early, so results are limited.
Phase 1 • Sponsor: Actym Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Can a simple test spot heart damage in cancer survivors?
Diagnosis Stopped earlyThis study looks at whether a special ECG and a blood test can find early signs of heart weakness in adult cancer survivors who had certain chemotherapy. Researchers will check how well these tests work compared to standard heart imaging. The goal is to gather information needed …
Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Aug 12, 2026 00:00 UTC
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Can retelling and deep breathing ease trauma in terminal cancer?
Symptom relief Stopped earlyThis Phase 2 trial tested a neuroscience-based technique combining memory structuring and deep vagal breathing to reduce PTSD symptoms in people with advanced, incurable cancer and their partners. The study enrolled 19 patients who had just received a terminal diagnosis. The appr…
Phase 2 • Sponsor: Centre Oscar Lambret • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Sarcoma lung surveillance study halted early: x-ray vs CT debate unresolved
Knowledge-focused Stopped earlyThis study aimed to compare chest X-ray and CT scans for detecting lung metastases in people who had surgery for high-grade soft tissue sarcoma. Only 11 patients were enrolled before the study was terminated early. The goal was to see which method better finds isolated, operable …
Phase 2 • Sponsor: Centre Oscar Lambret • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Sarcoma patients share their experience on a second chemo round
Knowledge-focused Stopped earlyThis study aimed to track how soft tissue sarcoma patients feel—symptoms, side effects, and quality of life—when they receive trabectedin chemotherapy again after a break. Only 7 patients were enrolled before the study was stopped early. The goal was to gather real-world patient …
Sponsor: Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Registry launched to understand young adult cancer Survivors' wellbeing
Knowledge-focused Stopped earlyThis observational registry aims to learn about the health, wellbeing, and needs of people who were diagnosed with cancer between ages 18 and 39. Participants complete surveys every 6 to 12 months about anxiety, depression, social support, and financial distress. The registry als…
Sponsor: Young Adult Survivors United • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Can a heart scan predict chemo danger?
Knowledge-focused Stopped earlyThis study aimed to find early markers of heart damage from chemotherapy in people with sarcoma. Researchers used advanced heart imaging (2D and 3D echocardiography) to track changes in heart function over time. The goal was to identify patients at highest risk for heart failure …
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC