Rheumatic heart disease

This study tests whether community health workers (CHWs) can help people with rheumatic heart disease (RHD) take their monthly antibiotic shots consistently. The trial will enroll about 308 participants in Brazil and Timor-Leste, including adults and children with RHD and their c…

This study will test if taking oral azithromycin pills for three days each month works as well as getting a monthly penicillin shot to prevent rheumatic heart disease from getting worse. The trial plans to enroll 474 Nigerian secondary school students aged 10-18 with mild or mode…

This study tests whether an AI tool called RADAR can help nurses in low-resource settings detect rheumatic heart disease more accurately using echocardiography. The goal is to make screening easier to scale up worldwide. The trial will enroll 62 nurse screeners at participating f…

This trial tests whether giving children aged 5 to 8 a twice-daily penicillin pill can prevent rheumatic heart disease, a serious condition that can damage heart valves. Researchers will compare children who take the antibiotic with those who do not, following them for three year…

People with rheumatic heart disease and atrial fibrillation take warfarin to prevent strokes, but the drug only works safely when blood clotting stays in a narrow target range. Researchers at Assiut University are studying about 90 Egyptian adults on warfarin for at least six mon…

This study follows 7,500 children aged 5 to 8 who live in areas where rheumatic heart disease is common. Each child gets a heart ultrasound once a year for three years to check for early signs of the disease. Researchers will count how many children develop rheumatic heart diseas…

This study tests a cloud-based tool called ACT+ to help people in Uganda get follow-up care after a positive screening for rheumatic heart disease. Researchers will work with local providers to improve the tool and then see if it increases the number of people who complete a conf…