Retinoblastoma

This study tests whether adding a chemotherapy drug (melphalan) injected directly into the eye can help treat a childhood eye cancer called retinoblastoma, especially when tumor seeds are floating in the eye fluid. About 26 children with newly diagnosed retinoblastoma will receiv…

This phase II trial is testing whether abemaciclib, a targeted cancer drug, can slow the growth of advanced bone and soft tissue sarcomas that have a specific alteration in the CDK pathway. Participants take the pill twice daily until their disease worsens or side effects become …

This phase 1 trial tests a drug called 177Lu-DTPA-omburtamab, which delivers radiation directly to tumor cells in children and teens with recurrent or refractory medulloblastoma or other central nervous system (CNS) tumors that have spread. The drug targets a protein called B7-H3…

This study compares two standard treatments for bleeding internal hemorrhoids: hemorrhoidal artery embolization (HAE) and rubber band ligation (RBL). HAE uses a catheter to block blood flow to the hemorrhoid with tiny particles or coils, while RBL uses rubber bands to cut off cir…

This phase 2 trial tests a chemotherapy eye implant (Episcleral Topotecan) in 30 children under 8 with advanced or recurrent retinoblastoma. The goal is to see if the implant can safely treat the eye tumor and avoid the need to remove the eye. Researchers are checking for side ef…

This study aims to improve survival and care for children with retinoblastoma, a rare eye cancer, in low-income African countries. Researchers will test whether following a set of treatment guidelines helps catch the disease early and leads to better outcomes. The study will enro…

This study tests two ways to treat retinoblastoma, a childhood eye cancer, while trying to save the eye and vision. One part compares two types of artery-directed chemotherapy (one with two drugs, one with one) to see which better preserves the eye. The other part looks at how we…

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…

This study investigates whether a blood marker called anti-Müllerian hormone (AMH) can predict future infertility in children and adolescents who have undergone cancer treatment. Many young patients recover normal menstrual cycles or puberty after chemotherapy, but their ovarian …

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a regist…

This study compares brain development in children who had multiple anesthesia exposures during retinoblastoma treatment to children who never had anesthesia. Researchers will use intelligence and memory tests to see if there are differences. The goal is to understand if anesthesi…

This study collects medical information and fluid from the front of the eye (aqueous humor) from up to 800 children with retinoblastoma, a rare eye cancer. Researchers aim to find biological markers in the fluid that can predict whether the eye can be saved with treatment. The st…

This study looks at the genes of 100 people with retinoblastoma, a rare eye cancer, to learn how changes in the RB1 gene cause the disease and related cancers. Participants give a blood or saliva sample for genetic testing. The goal is to better understand the link between a pers…

This study is testing whether a special type of MRI scan can predict how children with retinoblastoma, a rare eye cancer, will respond to chemotherapy delivered directly to the eye. Researchers will scan 60 children before treatment and check if the scan results match their respo…

This study collects tumor and blood samples from 1,000 children with solid cancers like neuroblastoma and sarcoma. Researchers will analyze the genetic makeup and immune response of these tumors to better understand how they grow and resist treatment. The goal is to gather knowle…

This study follows 900 children who were treated for retinoblastoma, a rare eye cancer, to track their long-term health. Researchers will collect vision tests, tissue and saliva samples, and questionnaires from patients and their siblings. The goal is to learn more about what cau…