Retinal disorder
MONDO:0005283Any disease or disorder of the retina.
Also known as: eye disease of retina, retina eye disease, retinopathy
959 clinical trials for this condition and its sub-types, 89 tagged with Retinal disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Retinal disorder
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Retinal degeneration 41 trials · 572 incl. sub-types
6 sub-types
- Inherited retinal dystrophy 41 trials · 510 incl. sub-types Sub-types →
- Macular degeneration 212 trials · 426 incl. sub-types Sub-types →
- Retinoschisis 5 trials · 6 incl. sub-types Sub-types →
- Peripheral retinal degeneration 1 trial · 2 incl. sub-types Sub-types →
- Cone dystrophy 1, X-linked 0 trials
- Cone dystrophy 5, X-linked 0 trials
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Retinal vascular disorder 9 trials · 324 incl. sub-types
12 sub-types
- Diabetic retinopathy 148 trials · 260 incl. sub-types Sub-types →
- Retinal vascular occlusion 0 trials · 53 incl. sub-types Sub-types →
- Exudative vitreoretinopathy 1 trial · 35 incl. sub-types Sub-types →
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations 3 trials
- Retinal telangiectasia 0 trials · 2 incl. sub-types Sub-types →
- Retinal vasculitis 2 trials
- Retinal hemangioblastoma 1 trial Sub-types →
- Retinal microaneurysm 1 trial
- Arteriosclerotic retinopathy 0 trials
- Familial retinal arterial macroaneurysm 0 trials
- Perifoveal exudative vascular anomalous complex 0 trials
- Vasoproliferative tumor of retina 0 trials
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Inherited vitreoretinopathy 0 trials · 58 incl. sub-types
5 sub-types
- Vitreoretinal degeneration 0 trials · 45 incl. sub-types Sub-types →
- Congenital vitreoretinal dysplasia 0 trials · 9 incl. sub-types Sub-types →
- Vitreous detachment 5 trials
- NDP-related vitreoretinopathy 0 trials Sub-types →
- TSPAN12-related vitreoretinopathy 0 trials Sub-types →
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Retinal detachment 28 trials · 52 incl. sub-types
2 sub-types
- Rhegmatogenous retinal detachment 23 trials Sub-types →
- Retinal perforation 18 trials
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Retina neoplasm 2 trials · 36 incl. sub-types
5 sub-types
- Retinal cancer 2 trials · 35 incl. sub-types Sub-types →
- Retinal cell neoplasm 0 trials · 34 incl. sub-types Sub-types →
- Benign neoplasm of retina 0 trials · 1 incl. sub-types Sub-types →
- Retinal capillary malformation 0 trials
- Retinal neuroblastoma 0 trials
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Retinal edema 1 trial · 28 incl. sub-types
1 sub-type
- Macular retinal edema 19 trials · 27 incl. sub-types Sub-types →
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Macular holes 19 trials
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Night blindness 5 trials · 10 incl. sub-types
3 sub-types
- Congenital stationary night blindness 2 trials · 5 incl. sub-types Sub-types →
- Abnormal threshold of rods 0 trials
- Acquired night blindness 0 trials
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Retinitis 1 trial · 10 incl. sub-types
5 sub-types
- Optic papillitis 5 trials Sub-types →
- Cytomegalovirus retinitis 2 trials
- Retinal vasculitis 2 trials
- Histoplasmosis retinitis 1 trial
- Acute retinal necrosis syndrome 0 trials
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Central serous chorioretinopathy 8 trials
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Proliferative vitreoretinopathy 7 trials
1 sub-type
- CAPN5-related vitreoretinopathy 0 trials
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Achromatopsia 4 trials · 6 incl. sub-types
6 sub-types
- Blue cone monochromacy 2 trials
- Achromatopsia 7 1 trial
- Achromatopsia 2 0 trials
- Achromatopsia 3 0 trials
- Achromatopsia 4 0 trials
- Achromatopsia 6 0 trials
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Retinal ciliopathy 0 trials · 2 incl. sub-types
9 sub-types
- Leber congenital amaurosis 10 2 trials
- Leber congenital amaurosis with early-onset deafness 0 trials
- Cone-rod dystrophy 16 0 trials
- Retinitis pigmentosa 23 0 trials
- Retinitis pigmentosa 51 0 trials
- Retinitis pigmentosa 55 0 trials
- Retinitis pigmentosa 64 0 trials
- Retinitis pigmentosa 74 0 trials
- Retinitis pigmentosa 80 0 trials
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Hypertensive retinopathy 1 trial
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Iris hypoplasia with glaucoma 1 trial
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Retinal ischemia 1 trial
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1 sub-type
- Neuroretinitis 0 trials
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Eales disease 0 trials
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Acute macular neuroretinopathy 0 trials
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Angioid streaks 0 trials
1 sub-type
- Angioid streaks of choroid 0 trials
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Autoimmune retinopathy 0 trials
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Bradyopsia 0 trials
2 sub-types
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Cancer-associated retinopathy 0 trials
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Isolated chorioretinal dystrophy 0 trials
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Isolated foveal hypoplasia 0 trials
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Melanoma associated retinopathy 0 trials
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Myopic macular degeneration 0 trials
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Persistent placoid maculopathy 0 trials
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Rubeosis iridis 0 trials
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Torpedo maculopathy 0 trials
Most studied deeper sub-types
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Tiny doses of avastin tested against laser for preemie eye disease
Disease control Stopped earlyThis study tested a low dose of the drug bevacizumab (Avastin) against standard laser treatment for retinopathy of prematurity, an eye disease that can blind premature infants. Sixteen babies with severe disease were enrolled. The goal was to see if the drug could control the dis…
Phase 3 • Sponsor: Jaeb Center for Health Research • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Can light therapy dry out a swollen retina?
Disease control Stopped earlyThis pilot study tests whether shining near-infrared light on the eye can reduce macular edema—swelling in the central retina—caused by a retinal vein occlusion. Six participants with this condition will receive 12 light treatments over about five weeks. The main goal is to see i…
Sponsor: University of Sydney • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New eye injection targets Blindness-Causing lesions
Disease control Stopped earlyThis early-stage study tests the safety of an experimental drug called RO7669330, given as an injection into the eye, for people with geographic atrophy (GA) due to age-related macular degeneration (AMD). The study involves 27 participants and will monitor side effects and eye he…
Phase 1 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Can an ancient herbal remedy ease swelling in the eye?
Disease control Stopped earlyThis phase 2 trial tests whether a modified Chinese herbal formula, Shenling Baizhu San, can reduce swelling in the retina (macular edema) and improve vision. Adults diagnosed with macular edema take either the herbal granules or a placebo twice daily for 12 weeks. The study meas…
Phase 2 • Sponsor: Chinese University of Hong Kong • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Eye stroke treatment put to the test: can clot busters save sight?
Disease control Stopped earlyThis study tested whether giving a clot-busting drug (tenecteplase or alteplase) within 4.5 hours of an eye stroke could restore vision. Eye stroke, or central retinal artery occlusion, is a blockage in the eye's main artery that often causes permanent vision loss. The trial aime…
Phase 3 • Sponsor: University Hospital Tuebingen • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Eye injection study for diabetes-related vision loss ends early
Disease control Stopped earlyThis study tested a single injection of avoralstat into the eye for people with diabetic macular edema, a condition that causes vision loss in diabetes. Only 3 adults took part before the study was stopped early. The main goal was to check safety and see if the drug might help re…
Phase 1 • Sponsor: BioCryst Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Experimental DME pill trial ends early after just one patient
Disease control Stopped earlyThis early-stage study tested a new oral drug called K9 for diabetic macular edema, a condition that causes vision loss in people with diabetes. The trial was stopped early and only enrolled one person. The main goal was to check safety and measure changes in retinal swelling and…
Phase 1 • Sponsor: Michelle Abou-Jaoude • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Gene therapy shot for dry AMD shows promise in early trial
Disease control Stopped earlyThis study tested a single injection of a gene therapy called GT005 in 98 people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes vision loss. The goal was to see if the treatment could slow the growth of damaged areas in the eye and c…
Phase 2 • Sponsor: Gyroscope Therapeutics Limited • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Gene therapy shot for dry AMD shows promise but trial halted early
Disease control Stopped earlyThis study tested a single injection of GT005, a gene therapy, in 255 people with geographic atrophy from dry age-related macular degeneration. The goal was to see if it could slow the growth of blind spots in the eye. The trial was terminated early, so we have less data than hop…
Phase 2 • Sponsor: Gyroscope Therapeutics Limited • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Experimental gene injection targets dry AMD
Disease control Stopped earlyThis early-stage trial tested a gene therapy called GT005 for dry age-related macular degeneration (AMD), a leading cause of vision loss. The therapy delivers a working gene to the retina via a single injection. The study enrolled 56 people and focused on safety and dosing, but w…
Phase 1/2 • Sponsor: Gyroscope Therapeutics Limited • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Experimental gene therapy aims to halt vision loss in rare blindness
Disease control Stopped earlyThis study tested a gene therapy for retinitis pigmentosa, an inherited eye disease that causes gradual vision loss. The treatment involved injecting a corrected gene under the retina in one eye. The trial included 19 people aged 13 and older with a specific genetic defect. The m…
Phase 1/2 • Sponsor: eyeDNA Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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VR headsets tested as a possible treatment for blindness
Disease control Stopped earlyThis study tested whether using a virtual reality headset for one-hour sessions could help regenerate damaged optic nerves and improve vision in people with glaucoma or other retinal diseases. The idea came from promising results in rodents. However, the trial was terminated earl…
Sponsor: Stanford University • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Eye injections tested to save sight in rare coats disease
Disease control Stopped earlyThis study tested whether anti-VEGF injections into the eye could help treat Coats disease, a rare condition that causes abnormal blood vessels and fluid buildup in the retina, potentially leading to blindness. The trial included 18 people with early-stage Coats disease who had n…
Phase 3 • Sponsor: Fondation Ophtalmologique Adolphe de Rothschild • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New surgical trick may fix stubborn eye holes
Disease control Stopped earlyThis study tested a new surgical technique for macular holes that remained open after standard treatment. The procedure involves moving a thin membrane from the eye to cover the hole. Only 16 people were enrolled, and the study was stopped early, so we don't yet know if this appr…
Sponsor: Groupe Hospitalier de la Region de Mulhouse et Sud Alsace • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Eye drug trial halted: could danicopan still slow blind spots?
Disease control Stopped earlyThis Phase 2 study tested an oral drug called danicopan in 365 people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes blind spots. Participants took different doses of danicopan or a placebo for up to 104 weeks to see if it could slow…
Phase 2 • Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 26, 2026 14:21 UTC
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Can your phone spot eye cancer? app tested for retinoblastoma
Diagnosis Stopped earlyThis study tested a smartphone app called CRADLE that uses a photo to detect leukocoria (a white glow in the pupil), which can be a sign of retinoblastoma, cataracts, or glaucoma. Researchers planned to compare the app's accuracy to a standard eye exam in children with these cond…
Sponsor: St. Jude Children's Research Hospital • Aim: Diagnosis
Last updated Sep 17, 2026 00:00 UTC
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AI reads eye photos to spot Diabetes-Related vision loss
Diagnosis Stopped earlyThis study tests whether an artificial intelligence program called NeoRetina can accurately detect diabetic retinopathy and diabetic macular edema from simple eye photographs. Researchers will compare the AI's analysis to standard exams by eye doctors. The goal is to see if this …
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) • Aim: Diagnosis
Last updated Jul 10, 2026 00:00 UTC
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New eye scanner software could sharpen diagnosis of macular degeneration
Diagnosis Stopped earlyThis study tested a new software called AngioScan, used with an already-approved eye camera, to see if it can take better pictures of the back of the eye. Researchers looked at 150 patients with retinal problems like macular degeneration. The goal was to find out if the software …
Sponsor: University of California, Los Angeles • Aim: Diagnosis
Last updated Jun 27, 2026 12:10 UTC
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Corn could be key to saving your eyesight
Prevention Stopped earlyThis study looked at whether eating corn rich in zeaxanthin (a natural pigment) could increase the density of the macular pigment in the eye, which may help prevent age-related macular degeneration (AMD), a leading cause of blindness. Nine healthy volunteers aged 20-35 ate a dail…
Sponsor: University Hospital, Bordeaux • Aim: Prevention
Last updated Jun 27, 2026 12:37 UTC
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Can genetics predict the worsening of geographic atrophy?
Knowledge-focused Stopped earlyThis study follows people with geographic atrophy, a severe form of age-related macular degeneration that causes blind spots, to see how their vision changes over time. Researchers will measure visual function, such as reading speed and sensitivity to light, and track the growth …
Sponsor: Hoffmann-La Roche • Aim: Knowledge-focused
Last updated Aug 28, 2026 00:00 UTC
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Tiny genetic clues may unlock eye disease mysteries
Knowledge-focused Stopped earlyThis study looked at people with cone disorders, a type of inherited eye disease that affects color vision and sharp sight. Researchers analyzed genetic changes of unknown significance to see if they cause disease. The goal was to improve genetic diagnosis, not to test a treatmen…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Eye test may forecast kidney failure after cancer surgery
Knowledge-focused Stopped earlyThis study looked at whether special eye scans (OCT-angiography) can predict how well the remaining kidney will work one year after kidney removal for cancer. Researchers enrolled 30 adults scheduled for total nephrectomy. The goal was to see if retinal blood vessel patterns coul…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Peeling eye membrane during retinal surgery: help or hype?
Knowledge-focused Stopped earlyThis study looked at whether peeling a thin membrane inside the eye (the internal limiting membrane) during surgery for a detached retina helps patients see better and prevents scar tissue. The trial was stopped early after enrolling only 21 people, so the results are not strong …
Sponsor: Vienna Institute for Research in Ocular Surgery • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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New eye camera could spot hidden signs of blindness
Knowledge-focused Stopped earlyThis study tested a new, non-invasive eye imaging method called hyperspectral imaging. It takes pictures of the back of the eye using many different colors of light to find details not visible with standard cameras. About 679 adults with healthy eyes or eye diseases like diabetic…
Sponsor: Center for Eye Research Australia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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New score could help eye surgeons predict who sees best after surgery
Knowledge-focused Stopped earlyThis study aimed to validate a scoring system that predicts whether patients will have good vision one year after combined cataract and epiretinal membrane surgery. The score uses factors like age, symptom duration, and initial vision. Researchers planned to enroll 164 adults age…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Rare disease study aims to map MLIV's natural course
Knowledge-focused Stopped earlyThis study followed 7 people with Mucolipidosis Type IV (MLIV) to learn how the disease naturally progresses. Researchers used tests like neuropsychological exams, blood and urine tests, and brain MRIs to find better ways to measure the disease. The goal was to improve future cli…
Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC
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Scientists dig into DNA to unravel rare eye disorders
Knowledge-focused Stopped earlyThis study looked at over 100 people with inherited retinal dystrophies, a group of rare eye diseases that can cause vision loss. Researchers collected genetic and eye exam data to find links between specific gene mutations and symptoms. The goal was to better understand these di…
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC