Restless legs syndrome

MONDO:0005391

A condition that occurs while resting or lying in bed; it is characterized by an irresistible urgency to move the legs to obtain relief from a strange and uncomfortable sensation in the legs.

Also known as: RLS, WED, restless leg syndrome

45 clinical trials for this condition and its sub-types, 45 tagged with Restless legs syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Nervous system disorder (26588)

Including sub-types (45) Tagged with Restless legs syndrome (45)

Trials to join now! 15 Not yet recruiting 14 Not yet finished but already full! 4 Completed 11 Terminated 1

Can a restless legs drug ease opioid withdrawal?

Symptom relief Stopped early

This study tested whether pramipexole (Mirapex), a drug for restless legs syndrome, could also reduce symptoms of opioid withdrawal in people with opioid use disorder. The trial planned to enroll 75 adults but was terminated early. Researchers measured changes in restless legs se…

Phase 2/3 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief

Last updated Jun 27, 2026 07:51 UTC

Restless legs syndrome

Where it sits in the disease tree

Can a restless legs drug ease opioid withdrawal?