Restless legs syndrome

Researchers test whether a home-based myofascial self-stretching program can ease symptoms of restless legs syndrome, also called Willis-Ekbom disease, in adults with chronic RLS. Participants do a 10- to 20-minute stretching routine each evening for two weeks and record their sy…

This trial tests whether a physical therapy technique called Muscle Energy Technique (MET) can reduce restless legs syndrome in people with end-stage kidney disease who are on hemodialysis. Participants receive either routine dialysis care or the same care plus MET during their d…

This study tests whether a non-invasive device that sends mild electrical pulses to nerves in the neck can reduce restless legs syndrome in people undergoing dialysis. Thirty-six adults aged 40-50 will receive either real or sham stimulation three times a week for four weeks. Res…

This study looked at whether a lumbar epidural steroid injection can reduce restless legs syndrome symptoms in 45 adults with lumbar central spinal stenosis. Participants received a standard injection as part of routine care, and their restless legs severity, pain, disability, an…

This study tested whether botulinum toxin type A (like Botox) can ease symptoms of restless legs syndrome (RLS) in 27 adults who did not get enough relief from standard treatments. Participants received one injection, and researchers checked if leg discomfort and urge to move imp…

This study tested whether Matrix Rhythm Therapy (MRT) — a gentle, hands-on treatment — can help women with Restless Legs Syndrome (RLS). 28 women received either MRT plus home exercises or home exercises alone for 5 weeks. Researchers measured changes in RLS severity, sleep quali…

This small study tested whether ecopipam, a drug that blocks a specific brain receptor, can help people with restless leg syndrome whose symptoms have gotten worse from their usual dopamine-based medication. Ten adults took either ecopipam or a placebo for six weeks, then switche…

This study looked at whether giving iron supplements to children with ADHD, restless legs syndrome, and low iron levels could improve their symptoms. Twelve kids aged 10-15 took iron for 3 months. Researchers measured changes in brain iron, blood iron, and symptoms using sleep mo…

This study tests whether a very short sleep survey, called the Sleep Vital Sign, can help primary care doctors recognize sleep disorders like sleep apnea, insomnia, and restless leg syndrome. About 1,260 adults visiting their Kaiser Permanente doctor will fill out the survey, whi…

This study looked at 102 adults to see how common restless legs syndrome is in people with temporomandibular joint (jaw) disorders. Researchers also checked if having both conditions affects sleep quality and daily life. Participants filled out questionnaires about their symptoms…

This completed study looked for genetic and environmental factors that increase the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including Parkinson's patients, people with related brain diseases, and healthy voluntee…