Preretinal fibrosis
MONDO:0002174A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)
Also known as: macular puckering of retina
35 clinical trials for this condition and its sub-types, 21 tagged with Preretinal fibrosis itself.
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A simple blood draw might reveal hidden eye lymphoma
Diagnosis CompletedThis study tests whether a blood test can help doctors tell apart uveitis caused by lymphoma from other types of uveitis. Uveitis is an eye inflammation that can lead to vision loss, and in some cases it is a sign of a rare eye lymphoma that may spread to the brain. The researche…
Sponsor: Hospices Civils de Lyon • Aim: Diagnosis
Last updated Sep 03, 2026 00:00 UTC
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AI eye exam: could a computer beat your doctor at spotting diabetic blindness?
Diagnosis CompletedThis study tested an artificial intelligence (AI) algorithm to detect diabetic retinopathy and glaucoma from eye photos. Researchers compared the AI's accuracy to that of family doctors and retina specialists. The goal was to see if AI could be a reliable screening tool in primar…
Sponsor: Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina • Aim: Diagnosis
Last updated Jul 11, 2026 00:00 UTC
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Eye drops before surgery may boost vision recovery
Symptom relief CompletedThis trial tests whether adding nepafenac eye drops before and after surgery for epiretinal membrane (a wrinkle on the retina) can help the eye heal faster. Sixty adults with this condition will either receive the drops plus standard care or standard care alone. Researchers will …
Phase 4 • Sponsor: Ankara Yildirim Beyazıt University • Aim: Symptom relief
Last updated Aug 01, 2026 00:00 UTC
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Built-In eye scanner could give surgeons a live 3D view during operations
Knowledge-focused CompletedThis study tests a microscope that has an OCT scanner built directly into it, allowing surgeons to take detailed cross-sectional images of the eye during surgery. The goal is to see if this setup is practical and whether the extra visual information helps guide surgical decisions…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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Blood thinners may be safe during retina surgery, study suggests
Knowledge-focused CompletedThis completed French study followed 748 adults undergoing retina/vitreous surgery to see if taking blood thinners (anticoagulants or antiplatelets) raises the risk of bleeding complications. Researchers compared patients who continued or stopped their medication with those not o…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Scientists probe eye fluids to unlock secrets of retinal detachment
Knowledge-focused CompletedThis completed study looked at fluid samples from the eyes of 137 people undergoing surgery for retinal detachment or other eye conditions. Researchers measured fats and proteins in these fluids to understand inflammation and cell death that can harm vision after surgery. The goa…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC