Pregnancy loss, recurrent, susceptibility to, 1

This study tests whether giving tranexamic acid (TXA) before a second-trimester dilation and evacuation (D&E) procedure can reduce heavy bleeding. Heavy bleeding is a rare but serious risk of D&E. The trial will include 276 pregnant people aged 18 and older who are between 18 and…

This phase 2 trial tests whether a single dose of cabergoline can prevent breast engorgement, milk leakage, and tenderness after abortion or pregnancy loss at 12-18 weeks. About 348 participants will receive either cabergoline or a placebo right after the procedure and report sym…

This study tests whether adding diphenhydramine (an antihistamine) to standard sedation medicine reduces pain during first-trimester abortion. About 98 adults will receive either diphenhydramine or a placebo alongside usual care. The goal is to see if this simple addition improve…

This study tests whether a paracervical block (an injection near the cervix) containing ketorolac and lidocaine can reduce pain during placement of osmotic dilators, which are used to prepare the cervix for a second-trimester abortion. About 76 participants will be randomly assig…

This study is looking at whether women with lower ovarian reserve (fewer eggs) have had more early miscarriages in the past. Researchers will measure ovarian reserve with a blood test (AMH) and an ultrasound (antral follicle count) in over 2,000 women seeking fertility care. This…

This study is following 20,000 women in China who had an induced abortion early in pregnancy (before 12 weeks). Researchers want to see if having an abortion in the past leads to more complications or problems in later pregnancies. The women will be tracked over time to compare t…