Post-cardiac arrest syndrome

After cardiac arrest, the brain often suffers from low oxygen even when the heart is restarted. This pilot trial tests whether using a non-invasive forehead sensor to monitor brain oxygen and adjust ICU treatments can keep oxygen levels above a target. Adults who remain in a coma…

This trial asks whether cooling the body to 33-34°C after a cardiac arrest treated with ECMO improves survival and brain function compared to keeping a normal temperature. It includes adults aged 18-75 who had an out-of-hospital cardiac arrest with certain heart rhythms. Particip…

This phase 2 trial tests whether giving high-dose vitamin C and thiamine early after cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after cardiac arrest and need blood pressure support will be randomly assigned to get either standard …

This study tests whether a group of treatments (like controlling body temperature, oxygen levels, blood pressure, and blood sugar) can improve brain function in adults who remain unconscious after a cardiac arrest. About 1,000 participants will be randomly assigned to receive eit…

This study follows 600 people who survived a cardiac arrest to understand what influences their short- and long-term recovery. Researchers will track survival, neurological and functional outcomes, and quality of life. They will also examine the emotional well-being and resilienc…

This study looks at whether long-term stress, measured by cortisol levels in hair, is linked to cardiac arrest. Researchers will take a small hair sample from 136 patients who had a cardiac arrest or heart attack. The goal is to see if higher stress levels over the past three mon…

This study follows people who survived a cardiac arrest and received ultra-rapid cooling treatment in a previous study. Researchers will check their health and survival status over 5 years through phone interviews and medical records. The goal is to understand the long-term effec…

This study aims to uncover the molecular causes of secondary brain injury in patients who survive cardiac arrest. Researchers will analyze cerebrospinal fluid from 60 participants using advanced techniques to identify changes in genes, proteins, and other molecules. The goal is t…

This study watches 250 adults who are unconscious after a cardiac arrest to see if early brain tests can predict when they will wake up. Researchers use tools like EEG and ultrasound to monitor the brain. The goal is to find reliable signs of recovery, not to test a new treatment…